PMID- 10072077
OWN - NLM
STAT- MEDLINE
DCOM- 19990325
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 10
IP  - 2
DP  - 1999 Feb
TI  - Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
PG  - 249-59
AB  - Many cytokines activate two highly homologous Stat proteins, 5a and 5b. Mice
      deficient in both genes lack all growth hormone and prolactin functions but
      retain functions associated with cytokines such as erythropoietin. Here, we
      demonstrate that, while lymphoid development is normal, Stat5a/b mutant
      peripheral T cells are profoundly deficient in proliferation and fail to undergo 
      cell cycle progression or to express genes controlling cell cycle progression. In
      addition, the mice lack NK cells, develop splenomegaly, and have T cells with an 
      activated phenotype, phenotypes seen in IL-2 receptor beta chain-deficient mice. 
      These phenotypes are not seen in mice lacking Stat5a or Stat5b alone. The results
      demonstrate that the Stat5 proteins, redundantly, are essential mediators of IL-2
      signaling in T cells.
FAU - Moriggl, R
AU  - Moriggl R
AD  - Howard Hughes Medical Institute, and Department of Biochemistry, St. Jude
      Children's Research Hospital, Memphis, Tennessee 38105, USA.
FAU - Topham, D J
AU  - Topham DJ
FAU - Teglund, S
AU  - Teglund S
FAU - Sexl, V
AU  - Sexl V
FAU - McKay, C
AU  - McKay C
FAU - Wang, D
AU  - Wang D
FAU - Hoffmeyer, A
AU  - Hoffmeyer A
FAU - van Deursen, J
AU  - van Deursen J
FAU - Sangster, M Y
AU  - Sangster MY
FAU - Bunting, K D
AU  - Bunting KD
FAU - Grosveld, G C
AU  - Grosveld GC
FAU - Ihle, J N
AU  - Ihle JN
LA  - eng
GR  - CA21765/CA/NCI NIH HHS/United States
GR  - P01 HL53749/HL/NHLBI NIH HHS/United States
GR  - R01 DK42932/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interleukin-2)
RN  - 0 (Milk Proteins)
RN  - 0 (STAT5 Transcription Factor)
RN  - 0 (Stat5a protein, mouse)
RN  - 0 (Stat5b protein, mouse)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Animals
MH  - Cell Cycle/*physiology
MH  - Cell Division
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/*physiology
MH  - Flow Cytometry
MH  - Interleukin-2/*physiology
MH  - Mice
MH  - Mice, Mutant Strains
MH  - *Milk Proteins
MH  - STAT5 Transcription Factor
MH  - T-Lymphocytes/*cytology
MH  - Thymus Gland/cytology/metabolism
MH  - Trans-Activators/*physiology
EDAT- 1999/03/11 00:00
MHDA- 1999/03/11 00:01
CRDT- 1999/03/11 00:00
PHST- 1999/03/11 00:00 [pubmed]
PHST- 1999/03/11 00:01 [medline]
PHST- 1999/03/11 00:00 [entrez]
AID - S1074-7613(00)80025-4 [pii]
AID - 10.1016/s1074-7613(00)80025-4 [doi]
PST - ppublish
SO  - Immunity. 1999 Feb;10(2):249-59. doi: 10.1016/s1074-7613(00)80025-4.