PMID- 10069364
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 445
IP  - 1
DP  - 1999 Feb 19
TI  - Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the
      mouse testis and localized in the principal piece of the sperm tail.
PG  - 9-13
AB  - Tissue distribution and cellular localization of rhophilin, a 71 kDa Rho-binding 
      protein, were examined in mice. Rhophilin mRNA was highly expressed in adult
      testis, but was absent in the testis of W/WV mice deficient in germ cells. An
      anti-rhophilin antibody detected a band of an expected size in sperm extracts,
      which was enriched in the tail fraction. Immunofluorescence analysis revealed two
      lines of striated staining running in parallel in the principal piece of the
      sperm tail. These results suggest that rhophilin is expressed in germ cells and
      localized in the fibrous sheath of the sperm tail.
FAU - Nakamura, K
AU  - Nakamura K
AD  - Department of Pharmacology, Kyoto University Faculty of Medicine, Japan.
FAU - Fujita, A
AU  - Fujita A
FAU - Murata, T
AU  - Murata T
FAU - Watanabe, G
AU  - Watanabe G
FAU - Mori, C
AU  - Mori C
FAU - Fujita, J
AU  - Fujita J
FAU - Watanabe, N
AU  - Watanabe N
FAU - Ishizaki, T
AU  - Ishizaki T
FAU - Yoshida, O
AU  - Yoshida O
FAU - Narumiya, S
AU  - Narumiya S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (rhophilin)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.2 (rho GTP-Binding Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Female
MH  - GTP Phosphohydrolases/*metabolism
MH  - GTP-Binding Proteins/genetics/*metabolism
MH  - Gene Expression
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - *Protein-Serine-Threonine Kinases
MH  - Sperm Tail/*metabolism
MH  - Testis/*metabolism
MH  - rho GTP-Binding Proteins
EDAT- 1999/03/09 00:00
MHDA- 1999/03/09 00:01
CRDT- 1999/03/09 00:00
PHST- 1999/03/09 00:00 [pubmed]
PHST- 1999/03/09 00:01 [medline]
PHST- 1999/03/09 00:00 [entrez]
AID - S0014579399000873 [pii]
AID - 10.1016/s0014-5793(99)00087-3 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Feb 19;445(1):9-13. doi: 10.1016/s0014-5793(99)00087-3.