PMID- 10069337
OWN - NLM
STAT- MEDLINE
DCOM- 19990330
LR  - 20220228
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 22
IP  - 2
DP  - 1999 Feb
TI  - Mena is required for neurulation and commissure formation.
PG  - 313-25
AB  - Mammalian enabled (Mena) is a member of a protein family thought to link signal
      transduction pathways to localized remodeling of the actin cytoskeleton. Mena
      binds directly to Profilin, an actin-binding protein that modulates actin
      polymerization. In primary neurons, Mena is concentrated at the tips of growth
      cone filopodia. Mena-deficient mice are viable; however, axons projecting from
      interhemispheric cortico-cortical neurons are misrouted in early neonates, and
      failed decussation of the corpus callosum as well as defects in the hippocampal
      commissure and the pontocerebellar pathway are evident in the adult.
      Mena-deficient mice that are heterozygous for a Profilin I deletion die in utero 
      and display defects in neurulation, demonstrating an important functional role
      for Mena in regulation of the actin cytoskeleton.
FAU - Lanier, L M
AU  - Lanier LM
AD  - Department of Biology, Massachusetts Institute of Technology, Cambridge 02139,
      USA.
FAU - Gates, M A
AU  - Gates MA
FAU - Witke, W
AU  - Witke W
FAU - Menzies, A S
AU  - Menzies AS
FAU - Wehman, A M
AU  - Wehman AM
FAU - Macklis, J D
AU  - Macklis JD
FAU - Kwiatkowski, D
AU  - Kwiatkowski D
FAU - Soriano, P
AU  - Soriano P
FAU - Gertler, F B
AU  - Gertler FB
LA  - eng
GR  - GM53236/GM/NIGMS NIH HHS/United States
GR  - HD18655/HD/NICHD NIH HHS/United States
GR  - HD28478/HD/NICHD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Carrier Proteins)
RN  - 0 (Contractile Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Enah protein, mouse)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Pfn1 protein, mouse)
RN  - 0 (Profilins)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/physiology
MH  - Axons/physiology
MH  - Brain/*embryology
MH  - Carrier Proteins/genetics/*physiology
MH  - *Contractile Proteins
MH  - *Cytoskeletal Proteins
MH  - Embryo, Mammalian/physiology
MH  - Embryonic and Fetal Development/physiology
MH  - Gene Deletion
MH  - Growth Cones/physiology
MH  - Mice/embryology
MH  - Microfilament Proteins/genetics
MH  - Mutation/physiology
MH  - Nervous System/*embryology
MH  - Profilins
MH  - Tissue Distribution
EDAT- 1999/03/09 00:00
MHDA- 1999/03/09 00:01
CRDT- 1999/03/09 00:00
PHST- 1999/03/09 00:00 [pubmed]
PHST- 1999/03/09 00:01 [medline]
PHST- 1999/03/09 00:00 [entrez]
AID - S0896-6273(00)81092-2 [pii]
AID - 10.1016/s0896-6273(00)81092-2 [doi]
PST - ppublish
SO  - Neuron. 1999 Feb;22(2):313-25. doi: 10.1016/s0896-6273(00)81092-2.