PMID- 10069332
OWN - NLM
STAT- MEDLINE
DCOM- 19990330
LR  - 20220309
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 22
IP  - 2
DP  - 1999 Feb
TI  - Gene targeting reveals a critical role for neurturin in the development and
      maintenance of enteric, sensory, and parasympathetic neurons.
PG  - 253-63
AB  - Neurturin (NTN) is a neuronal survival factor that activates the Ret tyrosine
      kinase in the presence of a GPI-linked coreceptor (either GFR alpha1 or GFR
      alpha2). Neurturin-deficient (NTN-/-) mice generated by homologous recombination 
      are viable and fertile but have defects in the enteric nervous system, including 
      reduced myenteric plexus innervation density and reduced gastrointestinal
      motility. Parasympathetic innervation of the lacrimal and submandibular salivary 
      gland is dramatically reduced in NTN-/- mice, indicating that Neurturin is a
      neurotrophic factor for parasympathetic neurons. GFR alpha2-expressing cells in
      the trigeminal and dorsal root ganglia are also depleted in NTN-/- mice. The loss
      of GFR alpha2-expressing neurons, in conjunction with earlier studies, provides
      strong support for GFR alpha2/Ret receptor complexes as the critical mediators of
      NTN function in vivo.
FAU - Heuckeroth, R O
AU  - Heuckeroth RO
AD  - Department of Pediatrics, Washington University School of Medicine, St. Louis,
      Missouri 63110, USA.
FAU - Enomoto, H
AU  - Enomoto H
FAU - Grider, J R
AU  - Grider JR
FAU - Golden, J P
AU  - Golden JP
FAU - Hanke, J A
AU  - Hanke JA
FAU - Jackman, A
AU  - Jackman A
FAU - Molliver, D C
AU  - Molliver DC
FAU - Bardgett, M E
AU  - Bardgett ME
FAU - Snider, W D
AU  - Snider WD
FAU - Johnson, E M Jr
AU  - Johnson EM Jr
FAU - Milbrandt, J
AU  - Milbrandt J
LA  - eng
GR  - R01 DK034153/DK/NIDDK NIH HHS/United States
GR  - KO8 HD01166-01/HD/NICHD NIH HHS/United States
GR  - R01 AG13729/AG/NIA NIH HHS/United States
GR  - R01 AG13730/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Drosophila Proteins)
RN  - 0 (Gfra2 protein, mouse)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor Receptors)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurturin)
RN  - 0 (Nrtn protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Ret protein, Drosophila)
RN  - EC 2.7.10.1 (Ret protein, mouse)
SB  - IM
CIN - Neuron. 1999 Feb;22(2):201-3. PMID: 10069322
MH  - Animals
MH  - *Drosophila Proteins
MH  - Gene Targeting
MH  - Glial Cell Line-Derived Neurotrophic Factor Receptors
MH  - Intestines/*innervation
MH  - Lacrimal Apparatus/innervation
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Nerve Growth Factors/deficiency/genetics/*physiology
MH  - Neurons/*physiology
MH  - Neurons, Afferent/metabolism/*physiology
MH  - Neurturin
MH  - Parasympathetic Nervous System/cytology/growth & development/*physiology
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-ret
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Salivary Glands/innervation
EDAT- 1999/03/09 03:01
MHDA- 2001/03/28 10:01
CRDT- 1999/03/09 03:01
PHST- 1999/03/09 03:01 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/03/09 03:01 [entrez]
AID - S0896-6273(00)81087-9 [pii]
AID - 10.1016/s0896-6273(00)81087-9 [doi]
PST - ppublish
SO  - Neuron. 1999 Feb;22(2):253-63. doi: 10.1016/s0896-6273(00)81087-9.