PMID- 10068680
OWN - NLM
STAT- MEDLINE
DCOM- 19990330
LR  - 20091119
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 93
IP  - 6
DP  - 1999 Mar 15
TI  - Cyclin A1 expression in leukemia and normal hematopoietic cells.
PG  - 2067-74
AB  - Human cyclin A1 is a newly cloned, tissue-specific cyclin that is prominently
      expressed in normal testis. In this study, we showed that cyclin A1 was highly
      expressed in a subset of leukemia samples from patients. The highest frequency of
      cyclin A1 overexpression was observed in acute myelocytic leukemias, especially
      those that were at the promyelocyte (M3) and myeloblast (M2) stages of
      development. Cyclin A1 expression was also detected in normal CD34(+) progenitor 
      cells. The expression of cyclin A1 increased when these cells were stimulated to 
      undergo myeloid differentiation in vitro. Taken together, our observations
      suggest that cyclin A1 may have a role in hematopoiesis. High levels of cyclin A1
      expression are especially associated with certain leukemias blocked at the
      myeloblast and promyelocyte stages of differentiation.
FAU - Yang, R
AU  - Yang R
AD  - Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of 
      Medicine, Los Angeles, CA, USA.
FAU - Nakamaki, T
AU  - Nakamaki T
FAU - Lubbert, M
AU  - Lubbert M
FAU - Said, J
AU  - Said J
FAU - Sakashita, A
AU  - Sakashita A
FAU - Freyaldenhoven, B S
AU  - Freyaldenhoven BS
FAU - Spira, S
AU  - Spira S
FAU - Huynh, V
AU  - Huynh V
FAU - Muller, C
AU  - Muller C
FAU - Koeffler, H P
AU  - Koeffler HP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD34)
RN  - 0 (CCNA1 protein, human)
RN  - 0 (Cyclin A)
RN  - 0 (Cyclin A1)
RN  - 0 (RNA, Messenger)
SB  - AIM
SB  - IM
MH  - Antigens, CD34/analysis
MH  - Blotting, Northern
MH  - Cell Differentiation
MH  - Cyclin A/analysis/*genetics
MH  - Cyclin A1
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - *Gene Expression
MH  - Hematopoietic Stem Cells/immunology/*metabolism
MH  - Humans
MH  - Leukemia/*metabolism
MH  - Leukemia, Myeloid, Acute/metabolism
MH  - Leukemia, Promyelocytic, Acute/metabolism
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 1999/03/09 00:00
MHDA- 1999/03/09 00:01
CRDT- 1999/03/09 00:00
PHST- 1999/03/09 00:00 [pubmed]
PHST- 1999/03/09 00:01 [medline]
PHST- 1999/03/09 00:00 [entrez]
PST - ppublish
SO  - Blood. 1999 Mar 15;93(6):2067-74.