PMID- 10067895
OWN - NLM
STAT- MEDLINE
DCOM- 19990315
LR  - 20190621
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 397
IP  - 6721
DP  - 1999 Feb 25
TI  - The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt
      signals.
PG  - 707-10
AB  - Embryological and genetic evidence indicates that the vertebrate head is induced 
      by a different set of signals from those that organize trunk-tail development.
      The gene cerberus encodes a secreted protein that is expressed in anterior
      endoderm and has the unique property of inducing ectopic heads in the absence of 
      trunk structures. Here we show that the cerberus protein functions as a
      multivalent growth-factor antagonist in the extracellular space: it binds to
      Nodal, BMP and Wnt proteins via independent sites. The expression of cerberus
      during gastrulation is activated by earlier nodal-related signals in endoderm and
      by Spemann-organizer factors that repress signalling by BMP and Wnt. In order for
      the head territory to form, we propose that signals involved in trunk
      development, such as those involving BMP, Wnt and Nodal proteins, must be
      inhibited in rostral regions.
FAU - Piccolo, S
AU  - Piccolo S
AD  - Howard Hughes Medical Institute and Department of Biological Chemistry,
      University of California, Los Angeles 90095-1662, USA.
FAU - Agius, E
AU  - Agius E
FAU - Leyns, L
AU  - Leyns L
FAU - Bhattacharyya, S
AU  - Bhattacharyya S
FAU - Grunz, H
AU  - Grunz H
FAU - Bouwmeester, T
AU  - Bouwmeester T
FAU - De Robertis, E M
AU  - De Robertis EM
LA  - eng
GR  - E.0815/Telethon/Italy
GR  - R37 HD021502/HD/NICHD NIH HHS/United States
GR  - R37 HD021502-13/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Wnt Proteins)
RN  - 0 (Xenopus Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (cer1 protein, Xenopus)
RN  - 0 (ndr2 protein, zebrafish)
RN  - 0 (nodal1 protein, Xenopus)
SB  - IM
MH  - Animals
MH  - Bone Morphogenetic Proteins/*antagonists & inhibitors/genetics
MH  - *Embryonic Induction
MH  - Head/embryology
MH  - Intercellular Signaling Peptides and Proteins
MH  - Intracellular Signaling Peptides and Proteins
MH  - Protein Binding
MH  - Proteins/genetics/*physiology
MH  - Proto-Oncogene Proteins/*antagonists & inhibitors
MH  - RNA, Messenger/metabolism
MH  - *Signal Transduction
MH  - Transforming Growth Factor beta/*antagonists & inhibitors
MH  - Wnt Proteins
MH  - Xenopus
MH  - Xenopus Proteins
MH  - *Zebrafish Proteins
PMC - PMC2323273
MID - NIHMS43284
EDAT- 1999/03/06 03:12
MHDA- 2001/03/23 10:01
CRDT- 1999/03/06 03:12
PHST- 1999/03/06 03:12 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/03/06 03:12 [entrez]
AID - 10.1038/17820 [doi]
PST - ppublish
SO  - Nature. 1999 Feb 25;397(6721):707-10. doi: 10.1038/17820.