PMID- 10064599
OWN - NLM
STAT- MEDLINE
DCOM- 19990429
LR  - 20181113
IS  - 0261-4189 (Print)
IS  - 0261-4189 (Linking)
VI  - 18
IP  - 5
DP  - 1999 Mar 1
TI  - c-Jun functions as a calcium-regulated transcriptional activator in the absence
      of JNK/SAPK1 activation.
PG  - 1335-44
AB  - Calcium is the principal second messenger in the control of gene expression by
      electrical activity in neurons. Recruitment of the coactivator CREB-binding
      protein, CBP, by the prototypical calcium-responsive transcription factor, CREB
      and stimulation of CBP activity by nuclear calcium signals is one mechanism
      through which calcium influx into excitable cells activates gene expression. Here
      we show that another CBP-interacting transcription factor, c-Jun, can mediate
      transcriptional activation upon activation of L-type voltage-gated calcium
      channels. Calcium-activated transcription mediated by c-Jun functions in the
      absence of stimulation of the c-Jun N-terminal protein kinase (JNK/SAPK1)
      signalling pathway and does not require c-Jun amino acid residues Ser63 and
      Ser73, the two major phosphorylation sites that regulate c-Jun activity in
      response to stress signals. Similar to CREB-mediated transcription, activation of
      c-Jun-mediated transcription by calcium signals requires calcium/
      calmodulin-dependent protein kinases and is dependent on CBP function. These
      results identify c-Jun as a calcium-regulated transcriptional activator and
      suggest that control of coactivator function (i.e. recruitment of CBP and
      stimulation of CBP activity) is a general mechanism for gene regulation by
      calcium signals.
FAU - Cruzalegui, F H
AU  - Cruzalegui FH
AD  - Neurobiology Division, Medical Research Council Laboratory of Molecular Biology, 
      Hills Road, Cambridge CB2 2QH, UK.
FAU - Hardingham, G E
AU  - Hardingham GE
FAU - Bading, H
AU  - Bading H
LA  - eng
PT  - Journal Article
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Calcium Channels)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Trans-Activators)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - CREB-Binding Protein
MH  - Calcium/*metabolism
MH  - Calcium Channels/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinases/genetics/*metabolism
MH  - Cell Line
MH  - Cyclic AMP/metabolism
MH  - Enzyme Activation/genetics
MH  - Gene Expression Regulation/genetics
MH  - Genes, Reporter/genetics
MH  - Ion Channel Gating
MH  - JNK Mitogen-Activated Protein Kinases
MH  - Microscopy, Fluorescence
MH  - *Mitogen-Activated Protein Kinases
MH  - Mutation
MH  - Nuclear Proteins/genetics
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-jun/*metabolism
MH  - Recombinant Fusion Proteins
MH  - Signal Transduction
MH  - Trans-Activators/genetics
MH  - Transcription, Genetic/genetics
MH  - Transcriptional Activation/*genetics
PMC - PMC1171223
EDAT- 1999/03/04 00:00
MHDA- 1999/03/04 00:01
CRDT- 1999/03/04 00:00
PHST- 1999/03/04 00:00 [pubmed]
PHST- 1999/03/04 00:01 [medline]
PHST- 1999/03/04 00:00 [entrez]
AID - 10.1093/emboj/18.5.1335 [doi]
PST - ppublish
SO  - EMBO J. 1999 Mar 1;18(5):1335-44. doi: 10.1093/emboj/18.5.1335.