PMID- 10064314
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20180508
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 129
IP  - 2S Suppl
DP  - 1999 Feb
TI  - Human biotinidase isn't just for recycling biotin.
PG  - 485S-489S
LID - 10.1093/jn/129.2.485S [doi]
AB  - For years, the major role of biotin has been as the coenzyme for four
      carboxylases in humans. Although there has been evidence that biotin might have
      other functions, none has been firmly established. The discovery that human serum
      biotinidase has biotinyl-transferase activity, in addition to biotinidase
      hydrolase activity, presents new possibilities for the role of biotinidase in
      biotin metabolism. Specific transfer of biotin to histones by biotinidase
      provides a possible explanation for why biotin is found in the nucleus and the
      nature of its role in the regulation of protein transcription. Future studies
      will help to determine the functions of biotinidase in biotin metabolism and in
      disease states.
FAU - Hymes, J
AU  - Hymes J
AD  - Department of Human Genetics, Medical College of Virginia at Virginia
      Commonwealth University, Richmond 23298, USA.
FAU - Wolf, B
AU  - Wolf B
LA  - eng
GR  - DK33840/DK/NIDDK NIH HHS/United States
GR  - HD48258/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Coenzymes)
RN  - 0 (Histones)
RN  - 6SO6U10H04 (Biotin)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.12 (Biotinidase)
SB  - IM
MH  - Amidohydrolases/deficiency/*metabolism
MH  - Biological Transport
MH  - Biotin/*metabolism
MH  - Biotinidase
MH  - Biotinylation
MH  - Coenzymes
MH  - Histones/metabolism/physiology
MH  - Humans
RF  - 41
EDAT- 1999/03/04 00:00
MHDA- 1999/03/04 00:01
CRDT- 1999/03/04 00:00
PHST- 1999/03/04 00:00 [pubmed]
PHST- 1999/03/04 00:01 [medline]
PHST- 1999/03/04 00:00 [entrez]
AID - 10.1093/jn/129.2.485S [doi]
PST - ppublish
SO  - J Nutr. 1999 Feb;129(2S Suppl):485S-489S. doi: 10.1093/jn/129.2.485S.