PMID- 100557
OWN - NLM
STAT- MEDLINE
DCOM- 19781229
LR  - 20101118
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 121
IP  - 4
DP  - 1978 Oct
TI  - Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus.
PG  - 1585-90
AB  - Light chains associated with normal serum immunoglobulin can be resolved into a
      finite number of discrete focusing bands by isoelectric focusing. Four distinct
      light chain patterns can be distinguished among the inbred mouse strains. In the 
      present studies inheritance of the characteristic light chain patterns has been
      studied in the AKXL recombinant inbred lines (derived from C57L/J and AKR/J
      parental lines) and in the inbred Ly-2a,3a congenic line B6.PL-Ly-2aLy-3a/Cy as
      well as in individual backcross animals of an incipient Ly-2a,3a congenic strain.
      Virtually complete concordance was observed for the expression of light chains
      characteristic of phenotype B (AKR-J-like) and the expression of the Ly-2a,3a
      allele. This observation indicates that a locus controlling light chain structure
      and/or expression is closely linked (less than 2.6 map units) to the Ly-2,3 locus
      on mouse Chromosome 6. The locus controlling normal light chain IF-patterns has
      been designated Ef1.
FAU - Gibson, D M
AU  - Gibson DM
FAU - Taylor, B A
AU  - Taylor BA
FAU - Cherry, M
AU  - Cherry M
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Immunoglobulin Light Chains)
SB  - AIM
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - Female
MH  - *Genetic Linkage
MH  - Immunoglobulin Light Chains/*genetics
MH  - Isoelectric Focusing
MH  - Male
MH  - Mice
MH  - Mice, Inbred A
MH  - Mice, Inbred AKR
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred CBA
MH  - Mice, Inbred DBA
MH  - Mice, Inbred NZB
EDAT- 1978/10/01 00:00
MHDA- 1978/10/01 00:01
CRDT- 1978/10/01 00:00
PHST- 1978/10/01 00:00 [pubmed]
PHST- 1978/10/01 00:01 [medline]
PHST- 1978/10/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1978 Oct;121(4):1585-90.