PMID- 10052456
OWN - NLM
STAT- MEDLINE
DCOM- 19990318
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 96
IP  - 4
DP  - 1999 Feb 19
TI  - Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct
      topographic selectivity.
PG  - 541-51
AB  - Taste represents a major form of sensory input in the animal kingdom. In mammals,
      taste perception begins with the recognition of tastant molecules by unknown
      membrane receptors localized on the apical surface of receptor cells of the
      tongue and palate epithelium. We report the cloning and characterization of two
      novel seven-transmembrane domain proteins expressed in topographically distinct
      subpopulations of taste receptor cells and taste buds. These proteins are
      specifically localized to the taste pore and are members of a new group of G
      protein-coupled receptors distantly related to putative mammalian pheromone
      receptors. We propose that these genes encode taste receptors.
FAU - Hoon, M A
AU  - Hoon MA
AD  - National Institute of Dental and Craniofacial Research, National Institutes of
      Health, Bethesda, Maryland 20892, USA.
FAU - Adler, E
AU  - Adler E
FAU - Lindemeier, J
AU  - Lindemeier J
FAU - Battey, J F
AU  - Battey JF
FAU - Ryba, N J
AU  - Ryba NJ
FAU - Zuker, C S
AU  - Zuker CS
LA  - eng
SI  - GENBANK/AF127389
SI  - GENBANK/AF127390
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Antibodies)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (taste receptors, type 1)
RN  - 0 (taste receptors, type 2)
RN  - 147979-21-3 (gustducin)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - EC 3.6.5.1 (Transducin)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - GTP-Binding Proteins/*genetics
MH  - Gene Expression/physiology
MH  - Humans
MH  - In Situ Hybridization
MH  - Mammals
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neurons, Afferent/chemistry/physiology
MH  - RNA, Messenger/analysis
MH  - Rabbits
MH  - Rats
MH  - Receptors, Cell Surface/analysis/*genetics/immunology
MH  - *Receptors, G-Protein-Coupled
MH  - Sensory Receptor Cells/*chemistry/*physiology
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction/physiology
MH  - Taste Buds/*chemistry/*physiology
MH  - Transducin/analysis
EDAT- 1999/03/03 00:00
MHDA- 1999/03/03 00:01
CRDT- 1999/03/03 00:00
PHST- 1999/03/03 00:00 [pubmed]
PHST- 1999/03/03 00:01 [medline]
PHST- 1999/03/03 00:00 [entrez]
AID - S0092-8674(00)80658-3 [pii]
AID - 10.1016/s0092-8674(00)80658-3 [doi]
PST - ppublish
SO  - Cell. 1999 Feb 19;96(4):541-51. doi: 10.1016/s0092-8674(00)80658-3.