PMID- 10051606
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 5
DP  - 1999 Mar 2
TI  - The RD114/simian type D retrovirus receptor is a neutral amino acid transporter.
PG  - 2129-34
AB  - The RD114/simian type D retroviruses, which include the feline endogenous
      retrovirus RD114, all strains of simian immunosuppressive type D retroviruses,
      the avian reticuloendotheliosis group including spleen necrosis virus, and baboon
      endogenous virus, use a common cell-surface receptor for cell entry. We have used
      a retroviral cDNA library approach, involving transfer and expression of cDNAs
      from highly infectable HeLa cells to nonpermissive NIH 3T3 mouse cells, to clone 
      and identify this receptor. The cloned cDNA, denoted RDR, is an allele of the
      previously cloned neutral amino acid transporter ATB0 (SLC1A5). Both RDR and ATB0
      serve as retrovirus receptors and both show specific transport of neutral amino
      acids. We have localized the receptor by radiation hybrid mapping to a region of 
      about 500-kb pairs on the long arm of human chromosome 19 at q13.3. Infection of 
      cells with RD114/type D retroviruses results in impaired amino acid transport,
      suggesting a mechanism for virus toxicity and immunosuppression. The
      identification and functional characterization of this retrovirus receptor
      provide insight into the retrovirus life cycle and pathogenesis and will be an
      important tool for optimization of gene therapy using vectors derived from
      RD114/type D retroviruses.
FAU - Rasko, J E
AU  - Rasko JE
AD  - Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, 
      WA 98109-1024, USA.
FAU - Battini, J L
AU  - Battini JL
FAU - Gottschalk, R J
AU  - Gottschalk RJ
FAU - Mazo, I
AU  - Mazo I
FAU - Miller, A D
AU  - Miller AD
LA  - eng
SI  - GENBANK/AF102826
SI  - GENBANK/AF105230
GR  - P01 HL036444/HL/NHLBI NIH HHS/United States
GR  - P50 HL054881/HL/NHLBI NIH HHS/United States
GR  - HL36444/HL/NHLBI NIH HHS/United States
GR  - HL54881/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Amino Acid Transport System ASC)
RN  - 0 (Carrier Proteins)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Receptors, Virus)
RN  - 0 (Recombinant Proteins)
RN  - 0 (SLC1A5 protein, human)
RN  - 0 (Slc1a5 protein, mouse)
SB  - IM
SB  - X
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - *Amino Acid Transport System ASC
MH  - Animals
MH  - CHO Cells
MH  - Carrier Proteins/chemistry/genetics/*physiology
MH  - Cats
MH  - Cell Line
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - Cloning, Molecular
MH  - Cricetinae
MH  - Dogs
MH  - Genetic Therapy
MH  - HeLa Cells
MH  - Humans
MH  - Hylobates
MH  - Life Cycle Stages
MH  - Mice
MH  - Minor Histocompatibility Antigens
MH  - Molecular Sequence Data
MH  - Receptors, Virus/chemistry/genetics/*physiology
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Retroviruses, Simian/*physiology
MH  - Tumor Cells, Cultured
PMC - PMC26748
EDAT- 1999/03/03 00:00
MHDA- 1999/03/03 00:01
CRDT- 1999/03/03 00:00
PHST- 1999/03/03 00:00 [pubmed]
PHST- 1999/03/03 00:01 [medline]
PHST- 1999/03/03 00:00 [entrez]
AID - 10.1073/pnas.96.5.2129 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2129-34. doi: 10.1073/pnas.96.5.2129.