PMID- 10051567
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 5
DP  - 1999 Mar 2
TI  - Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.
PG  - 1904-9
AB  - The angiopoietins have recently joined the members of the vascular endothelial
      growth factor family as the only known growth factors largely specific for
      vascular endothelium. The angiopoietins include a naturally occurring agonist,
      angiopoietin-1, as well as a naturally occurring antagonist, angiopoietin-2, both
      of which act by means of the Tie2 receptor. We now report our attempts to use
      homology-based cloning approaches to identify new members of the angiopoietin
      family. These efforts have led to the identification of two new angiopoietins,
      angiopoietin-3 in mouse and angiopoietin-4 in human; we have also identified
      several more distantly related sequences that do not seem to be true
      angiopoietins, in that they do not bind to the Tie receptors. Although
      angiopoietin-3 and angiopoietin-4 are strikingly more structurally diverged from 
      each other than are the mouse and human versions of angiopoietin-1 and
      angiopoietin-2, they appear to represent the mouse and human counterparts of the 
      same gene locus, as revealed in our chromosomal localization studies of all of
      the angiopoietins in mouse and human. The structural divergence of angiopoietin-3
      and angiopoietin-4 appears to underlie diverging functions of these counterparts.
      Angiopoietin-3 and angiopoietin-4 have very different distributions in their
      respective species, and angiopoietin-3 appears to act as an antagonist, whereas
      angiopoietin-4 appears to function as an agonist.
FAU - Valenzuela, D M
AU  - Valenzuela DM
AD  - Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY
      10591, USA.
FAU - Griffiths, J A
AU  - Griffiths JA
FAU - Rojas, J
AU  - Rojas J
FAU - Aldrich, T H
AU  - Aldrich TH
FAU - Jones, P F
AU  - Jones PF
FAU - Zhou, H
AU  - Zhou H
FAU - McClain, J
AU  - McClain J
FAU - Copeland, N G
AU  - Copeland NG
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Huang, T
AU  - Huang T
FAU - Papadopoulos, N
AU  - Papadopoulos N
FAU - Maisonpierre, P C
AU  - Maisonpierre PC
FAU - Davis, S
AU  - Davis S
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
LA  - eng
SI  - GENBANK/AF113707
SI  - GENBANK/AF113708
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (ANGPT1 protein, human)
RN  - 0 (ANGPTL1 protein, human)
RN  - 0 (Angiopoietin-1)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Angiopoietins)
RN  - 0 (Angpt1 protein, mouse)
RN  - 0 (Growth Substances)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proteins)
RN  - 0 (angiopoietin 4)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, TIE-2)
SB  - IM
MH  - Amino Acid Sequence
MH  - Angiopoietin-1
MH  - Angiopoietin-like Proteins
MH  - *Angiopoietins
MH  - Animals
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 20
MH  - Chromosomes, Human, Pair 8
MH  - *Evolution, Molecular
MH  - Female
MH  - Genetic Variation
MH  - Growth Substances/chemistry/*genetics/metabolism
MH  - Humans
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Membrane Glycoproteins/chemistry/genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Pregnancy
MH  - Proteins/chemistry/*genetics/metabolism
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Receptor, TIE-2
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
PMC - PMC26709
EDAT- 1999/03/03 00:00
MHDA- 1999/03/03 00:01
CRDT- 1999/03/03 00:00
PHST- 1999/03/03 00:00 [pubmed]
PHST- 1999/03/03 00:01 [medline]
PHST- 1999/03/03 00:00 [entrez]
AID - 10.1073/pnas.96.5.1904 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1904-9. doi: 10.1073/pnas.96.5.1904.