PMID- 10051403
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20211203
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 2
DP  - 1999 Mar 1
TI  - Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1
      (KIAA0369), a homologue of DCX (XLIS).
PG  - 179-83
AB  - Human DCAMKL1, also known as KIAA0369, is a homologue of DCX (Xq22. 3), a gene
      associated with X-linked lissencephaly and subcortical band heterotopia. This
      suggests that DCAMKL1 may play a role in neuronal migration. The gene also shows 
      similarity to Ca2+/calmodulin-dependent protein kinases. We have determined its
      genomic structure, regional mapping, and expression pattern in human tissues.
      DCAMKL1 consists of at least 18 exons ranging from 58 to 3359 bp in length. We
      have characterized the exon/intron borders, and primers were designed to amplify 
      each individual exon for mutation analysis. DCAMKL1 was mapped to chromosome
      13q13 by fluorescence in situ hybridization. Northern blot analysis showed
      DCAMKL1 to be predominantly expressed in human fetal brain as a major transcript 
      of about 5.8 kb.
CI  - Copyright 1999 Academic Press.
FAU - Matsumoto, N
AU  - Matsumoto N
AD  - Department of Human Genetics, The University of Chicago, 924 E. 57th Street,
      Chicago, Illinois 60637, USA.
FAU - Pilz, D T
AU  - Pilz DT
FAU - Ledbetter, D H
AU  - Ledbetter DH
LA  - eng
SI  - GENBANK/AB002367
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DCX protein, human)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Phosphoproteins)
RN  - EC 2.7.1.11 (DCLK1 protein, human)
RN  - EC 2.7.1.11 (Doublecortin-Like Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Brain/embryology/metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13/genetics
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Doublecortin-Like Kinases
MH  - Exons
MH  - Female
MH  - Gene Expression
MH  - Gene Expression Regulation, Developmental
MH  - Genes/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intracellular Signaling Peptides and Proteins
MH  - Introns
MH  - Male
MH  - *Microtubule-Associated Proteins
MH  - Molecular Sequence Data
MH  - Neuropeptides/*genetics/metabolism
MH  - Phosphoproteins/*genetics
MH  - Protein Serine-Threonine Kinases
MH  - Tissue Distribution
MH  - Transcription, Genetic
EDAT- 1999/03/03 00:00
MHDA- 1999/03/03 00:01
CRDT- 1999/03/03 00:00
PHST- 1999/03/03 00:00 [pubmed]
PHST- 1999/03/03 00:01 [medline]
PHST- 1999/03/03 00:00 [entrez]
AID - S0888-7543(98)95673-7 [pii]
AID - 10.1006/geno.1998.5673 [doi]
PST - ppublish
SO  - Genomics. 1999 Mar 1;56(2):179-83. doi: 10.1006/geno.1998.5673.