PMID- 10051402
OWN - NLM
STAT- MEDLINE
DCOM- 19990422
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 2
DP  - 1999 Mar 1
TI  - Cloning and characterization of a novel beta integrin-related cDNA coding for the
      protein TIED ("ten beta integrin EGF-like repeat domains") that maps to
      chromosome band 13q33: A divergent stand-alone integrin stalk structure.
PG  - 169-78
AB  - Herein we describe the cDNA sequence of a novel human gene, ITGBL1, encoding a
      beta integrin-related protein termed TIED [for ten beta integrin epidermal growth
      factor (EGF)-like repeat domains]. Overlapping cDNA clones from fetal lung,
      HUVEC, and osteoblast cDNA libraries encode a sequence comprising a typical
      signal peptide, followed by a hydrophilic 471-amino-acid domain containing 10
      tandem EGF-like repeats strikingly similar to those found in the cysteine-rich
      "stalk-like" structure of integrin beta subunits. The EGF-like repeats of TIED
      and beta integrins are unique in that they alternate in homology and possess two 
      additional cysteines (eight in total) whose positions differ from those in the
      other eight-cysteine EGF-like domains of laminin, fibrillin, and the latent
      TGF-beta binding proteins. TIED mRNA transcripts of 2.8 kb were detected in
      aorta, thymus, and osteogenic sarcoma cells. The ITGBL1 gene was mapped to human 
      chromosome 13, band 13q33. We suggest that ITGBL1 may be linked in some way with 
      the evolution of the integrin beta subunits.
CI  - Copyright 1999 Academic Press.
FAU - Berg, R W
AU  - Berg RW
AD  - Faculty of Medicine and Health Science, The University of Auckland, Auckland, New
      Zealand.
FAU - Leung, E
AU  - Leung E
FAU - Gough, S
AU  - Gough S
FAU - Morris, C
AU  - Morris C
FAU - Yao, W P
AU  - Yao WP
FAU - Wang, S X
AU  - Wang SX
FAU - Ni, J
AU  - Ni J
FAU - Krissansen, G W
AU  - Krissansen GW
LA  - eng
SI  - GENBANK/AF072752
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (3' Untranslated Regions)
RN  - 0 (DNA, Complementary)
RN  - 0 (Integrins)
RN  - 0 (RNA, Messenger)
RN  - 62229-50-9 (Epidermal Growth Factor)
SB  - IM
MH  - 3' Untranslated Regions
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Binding Sites
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry/*genetics
MH  - Epidermal Growth Factor
MH  - Gene Expression Regulation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Integrins/chemistry/*genetics
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Tumor Cells, Cultured
EDAT- 1999/03/03 00:00
MHDA- 1999/03/03 00:01
CRDT- 1999/03/03 00:00
PHST- 1999/03/03 00:00 [pubmed]
PHST- 1999/03/03 00:01 [medline]
PHST- 1999/03/03 00:00 [entrez]
AID - S0888-7543(98)95707-X [pii]
AID - 10.1006/geno.1998.5707 [doi]
PST - ppublish
SO  - Genomics. 1999 Mar 1;56(2):169-78. doi: 10.1006/geno.1998.5707.