PMID- 10051316
OWN - NLM
STAT- MEDLINE
DCOM- 19990326
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 3
DP  - 1999 Mar
TI  - High-resolution comparative physical mapping of mouse chromosome 10 in the region
      of homology with human chromosome 21.
PG  - 229-34
AB  - Comparative mapping of human and mouse chromosomes can be used to predict
      locations of homologous loci between the species, provides the substrate to
      examine the process of chromosomal evolution, and facilitates the continuing
      development of mouse genetic models for human disorders. A YAC contig of the
      region of mouse Chromosome (Chr) 10 (MMU10) that demonstrates conserved linkage
      with the distal portion of human Chr 21 (HSA21) has been constructed. The contig 
      contains all known genes mapped in both species, defines the proximal region of
      homology between MMU10 and HSA22, and contains the evolutionary junction between 
      HSA21 and HSA22 on MMU10. It consists of 23 YACs and 2 PACs, and covers 3.2 Mb of
      MMU10. The average marker density for this region is 1 marker/69 kb. Nine of 22
      expressed sequences are mapped here for the first time in mouse, and two are
      newly characterized expressed sequences. The contig also contains 12 simple
      sequence repeats (SSRs) and 16 YAC and PAC endclone markers. YAC fragmentation
      analysis was used to create a physical map for the proximal 2.2 Mb of the contig.
      Cloning of the corresponding region of HSA21 has proven difficult, and the mouse 
      contig includes segments absent from previously described sequence ready maps of 
      HSA21.
FAU - Cole, S E
AU  - Cole SE
AD  - Department of Physiology, 205, Johns Hopkins University School of Medicine, 725
      N. Wolfe St., Baltimore, Maryland 21205, USA.
FAU - Wiltshire, T
AU  - Wiltshire T
FAU - Rue, E E
AU  - Rue EE
FAU - Morrow, D
AU  - Morrow D
FAU - Hieter, P
AU  - Hieter P
FAU - Brahe, C
AU  - Brahe C
FAU - Fisher, E M
AU  - Fisher EM
FAU - Katsanis, N
AU  - Katsanis N
FAU - Reeves, R H
AU  - Reeves RH
LA  - eng
GR  - HD24605/HD/NICHD NIH HHS/United States
GR  - HG00405/HG/NHGRI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (DNA Primers)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 21
MH  - DNA Primers
MH  - Humans
MH  - Mice
MH  - *Physical Chromosome Mapping
MH  - Polymerase Chain Reaction
MH  - Recombination, Genetic
MH  - Sequence Tagged Sites
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - 10.1007/s003359900978 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Mar;10(3):229-34. doi: 10.1007/s003359900978.