PMID- 10051314
OWN - NLM
STAT- MEDLINE
DCOM- 19990326
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 3
DP  - 1999 Mar
TI  - Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an
      enhancer-trap transgene integration locus.
PG  - 218-24
AB  - A novel mouse gene, associated with the enhancer-trap mutation TKZ736, has been
      cloned and sequenced. It encodes a polyspecific transmembrane transporter with 12
      putative transmembrane domains, that shares significant homology with the mouse
      organic cation transporter 1 (Oct1/Slc22a1) called Lx1. Like Oct1/Slc22a1/Lx1,
      this gene maps to the proximal part of Chromosome (Chr) 17, but shows a different
      expression pattern from Oct1/Slc22a1/Lx1. The gene identified here is
      predominantly expressed in the kidney and ureter, but no expression is detectable
      in liver. Sequence comparisons suggest that this novel gene most likely
      represents the mouse homolog of the rat organic cation transporter 2 gene. The
      genomic DNA flanking the 3' transgene integration site in the enhancer-trap
      mutation TKZ736 encodes the second exon of the Oct2/Slc22a2 gene.
FAU - Mooslehner, K A
AU  - Mooslehner KA
AD  - Laboratory of Cognitive and Developmental Neurobiology, The Babraham Institute,
      Babraham, Cambridge, CB2 4AT, UK.
FAU - Allen, N D
AU  - Allen ND
LA  - eng
SI  - GENBANK/AJ006036
SI  - GENBANK/AJ006037
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (Organic Cation Transport Proteins)
RN  - 0 (SLC22A5 protein, human)
RN  - 0 (Solute Carrier Family 22 Member 5)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Carrier Proteins/*genetics
MH  - Cloning, Molecular
MH  - Crosses, Genetic
MH  - DNA, Complementary
MH  - *Enhancer Elements, Genetic
MH  - Humans
MH  - Membrane Proteins/*genetics
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Mutation
MH  - *Organic Cation Transport Proteins
MH  - Sequence Homology, Amino Acid
MH  - Solute Carrier Family 22 Member 5
MH  - *Transgenes
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - 10.1007/s003359900976 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Mar;10(3):218-24. doi: 10.1007/s003359900976.