PMID- 10051313
OWN - NLM
STAT- MEDLINE
DCOM- 19990326
LR  - 20190905
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 10
IP  - 3
DP  - 1999 Mar
TI  - Jumbled spine and ribs (Jsr): a new mutation on mouse chromosome 5.
PG  - 213-7
AB  - Jumbled spine and ribs (Jsr) is an autosomal dominant mutation that results in
      malformation of the axial skeleton. The vertebrae of mutant mice (Jsr/+) are all 
      shorter than those of normal mice (+/+) in the inbred line and show various
      abnormalities. In addition, several ribs are fused at their proximal region
      because of fusion of thoracic vertebrae. In this study, we localized the Jsr
      mutation on distal Chromosome (Chr) 5 and constructed a high-resolution map.
      Chromosomal mapping was performed with an inter-subspecific backcross of
      (CKH-Jsr/+ x MOG) F1 carrying the Jsr allele and CKH-+/+. The predicted gene
      order around Jsr was determined to be cen-(Epo, Pdgfa, D5Mit31, D5Mit374)-(Jsr,
      Nfe2u, D5Mit99, D5Mit247, D5Mit284, D5Mit292, D5Mit327)-D5Mit328-tel.
      Subsequently, high-resolution mapping concluded the Jsr localization to be
      cen-Nfe2u-1.0cM-Jsr-0.2cM-D5Mit247,292-tel . Jsr/Jsr homozygotes are alive, as
      the mutation is not lethal. Based on histological analysis of mutant embryos, Jsr
      is hypothesized to be caused by abnormal development of primordial cells in the
      axial skeleton.
FAU - Miyoshi, H
AU  - Miyoshi H
AD  - Laboratory of Experimental Animal Science, Graduate School of Veterinary
      Medicine, Hokkaido University, Sapporo 060-0818, Japan.
FAU - Kon, Y
AU  - Kon Y
FAU - Seo, K W
AU  - Seo KW
FAU - Jin, H K
AU  - Jin HK
FAU - Hasegawa, A
AU  - Hasegawa A
FAU - Watanabe, T
AU  - Watanabe T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (DNA Primers)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - *Chromosomes, Human, Pair 5
MH  - DNA Primers
MH  - Homozygote
MH  - Humans
MH  - Mice
MH  - Mice, Mutant Strains
MH  - *Mutation
MH  - Ribs/*abnormalities
MH  - Spine/*abnormalities
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - 10.1007/s003359900975 [doi]
PST - ppublish
SO  - Mamm Genome. 1999 Mar;10(3):213-7. doi: 10.1007/s003359900975.