PMID- 10050855
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20161124
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 397
IP  - 6720
DP  - 1999 Feb 18
TI  - Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding
      protein.
PG  - 617-21
AB  - The Hedgehog signalling pathway is essential for the development of diverse
      tissues during embryogenesis. Signalling is activated by binding of Hedgehog
      protein to the multipass membrane protein Patched (Ptc). We have now identified a
      novel component in the vertebrate signalling pathway, which we name Hip (for
      Hedgehog-interacting protein) because of its ability to bind Hedgehog proteins.
      Hip encodes a membrane glycoprotein that binds to all three mammalian Hedgehog
      proteins with an affinity comparable to that of Ptc-1. Hip-expressing cells are
      located next to cells that express each Hedgehog gene. Hip expression is induced 
      by ectopic Hedgehog signalling and is lost in Hedgehog mutants. Thus, Hip, like
      Ptc-1, is a general transcriptional target of Hedgehog signalling. Overexpression
      of Hip in cartilage, where Indian hedgehog (Ihh) controls growth, leads to a
      shortened skeleton that resembles that seen when Ihh function is lost (B.
      St-Jacques, M. Hammerschmidt & A.P.M., in preparation). Our findings support a
      model in which Hip attenuates Hedgehog signalling as a result of binding to
      Hedgehog proteins: a negative regulatory feedback loop established in this way
      could thus modulate the responses to any Hedgehog signal.
FAU - Chuang, P T
AU  - Chuang PT
AD  - Department of Molecular and Cellular Biology, The Biolabs, Harvard University,
      Cambridge, Massachusetts 02138, USA.
FAU - McMahon, A P
AU  - McMahon AP
LA  - eng
SI  - GENBANK/AF116865
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Carrier Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Hhip protein, mouse)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Patched Receptors)
RN  - 0 (Patched-1 Receptor)
RN  - 0 (Proteins)
RN  - 0 (Ptch1 protein, mouse)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - COS Cells
MH  - Carrier Proteins/genetics/*metabolism
MH  - Embryonic and Fetal Development
MH  - Feedback
MH  - Gene Expression Regulation, Developmental
MH  - Hedgehog Proteins
MH  - Intracellular Signaling Peptides and Proteins
MH  - Membrane Glycoproteins/genetics/*metabolism
MH  - Membrane Proteins/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Patched Receptors
MH  - Patched-1 Receptor
MH  - Protein Binding
MH  - Proteins/*metabolism
MH  - Receptors, Cell Surface
MH  - Sequence Homology, Amino Acid
MH  - *Signal Transduction
MH  - *Trans-Activators
EDAT- 1999/03/02 03:05
MHDA- 2001/03/23 10:01
CRDT- 1999/03/02 03:05
PHST- 1999/03/02 03:05 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/03/02 03:05 [entrez]
AID - 10.1038/17611 [doi]
PST - ppublish
SO  - Nature. 1999 Feb 18;397(6720):617-21. doi: 10.1038/17611.