PMID- 10049942
OWN - NLM
STAT- MEDLINE
DCOM- 19990602
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 0022-1007 (Linking)
VI  - 189
IP  - 5
DP  - 1999 Mar 1
TI  - NKp44, a triggering receptor involved in tumor cell lysis by activated human
      natural killer cells, is a novel member of the immunoglobulin superfamily.
PG  - 787-96
AB  - Surface receptors involved in natural killer (NK) cell triggering during the
      process of tumor cell lysis have recently been identified. Of these receptors,
      NKp44 is selectively expressed by IL-2- activated NK cells and may contribute to 
      the increased efficiency of activated NK cells to mediate tumor cell lysis. Here 
      we describe the molecular cloning of NKp44. Analysis of the cloned cDNA indicated
      that NKp44 is a novel transmembrane glycoprotein belonging to the Immunoglobulin 
      superfamily characterized by a single extracellular V-type domain. The charged
      amino acid lysine in the transmembrane region may be involved in the association 
      of NKp44 with the signal transducing molecule killer activating
      receptor-associated polypeptide (KARAP)/DAP12. These molecules were found to be
      crucial for the surface expression of NKp44. In agreement with data of NKp44
      surface expression, the NKp44 transcripts were strictly confined to activated NK 
      cells and to a minor subset of TCR-gamma/delta+ T lymphocytes. Unlike genes
      coding for other receptors involved in NK cell triggering or inhibition, the
      NKp44 gene is on human chromosome 6.
FAU - Cantoni, C
AU  - Cantoni C
AD  - Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate,
      16132 Genova, Italy.
FAU - Bottino, C
AU  - Bottino C
FAU - Vitale, M
AU  - Vitale M
FAU - Pessino, A
AU  - Pessino A
FAU - Augugliaro, R
AU  - Augugliaro R
FAU - Malaspina, A
AU  - Malaspina A
FAU - Parolini, S
AU  - Parolini S
FAU - Moretta, L
AU  - Moretta L
FAU - Moretta, A
AU  - Moretta A
FAU - Biassoni, R
AU  - Biassoni R
LA  - eng
SI  - GENBANK/AJ225109
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA, Complementary)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Proteins)
RN  - 0 (NCR2 protein, human)
RN  - 0 (Natural Cytotoxicity Triggering Receptor 2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TYROBP protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - COS Cells
MH  - Cell Compartmentation
MH  - Chromosomes, Human, Pair 6
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - *Cytotoxicity, Immunologic
MH  - DNA, Complementary/genetics
MH  - Humans
MH  - Immunoglobulins/classification/*genetics/immunology/metabolism
MH  - Killer Cells, Natural/*immunology
MH  - Lymphocyte Subsets/immunology
MH  - Membrane Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Natural Cytotoxicity Triggering Receptor 2
MH  - Protein Binding
MH  - RNA, Messenger/isolation & purification
MH  - Receptors, Immunologic/classification/*genetics/immunology/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - Species Specificity
PMC - PMC2192947
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - 10.1084/jem.189.5.787 [doi]
PST - ppublish
SO  - J Exp Med. 1999 Mar 1;189(5):787-96. doi: 10.1084/jem.189.5.787.