PMID- 10049774
OWN - NLM
STAT- MEDLINE
DCOM- 19990401
LR  - 20041117
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 255
IP  - 3
DP  - 1999 Feb 24
TI  - Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in
      normal versus malignant cells.
PG  - 703-6
AB  - Chemokines are a family of related proteins that regulate leukocyte infiltration 
      into inflamed tissue and play important roles in many disease processes.
      Chemokines are divided into two major groups, CC or CXC, based on their sequence 
      around the amino terminal cysteines. We report the PCR cloning of a novel human
      chemokine termed BRAK for its initial isolation from breast and kidney cells.
      This novel chemokine is distantly related to other CXC chemokines (30% identity
      with MIP-2alpha and beta) and shares several biological activities. BRAK is
      expressed ubiquitously and highly in normal tissue. However, it was expressed in 
      only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31.
CI  - Copyright 1999 Academic Press.
FAU - Hromas, R
AU  - Hromas R
AD  - Department of Hematology and Oncology, Walther Oncology Center, Indiana
      University Medical Center, R4-202, 1044 W. Walnut Street, Indianapolis, Indiana, 
      46202, USA.hromas@iupui.edu
FAU - Broxmeyer, H E
AU  - Broxmeyer HE
FAU - Kim, C
AU  - Kim C
FAU - Nakshatri, H
AU  - Nakshatri H
FAU - Christopherson, K 2nd
AU  - Christopherson K 2nd
FAU - Azam, M
AU  - Azam M
FAU - Hou, Y H
AU  - Hou YH
LA  - eng
SI  - GENBANK/AF073957
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (CXCL14 protein, human)
RN  - 0 (Chemokines, CXC)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chemokines, CXC/chemistry/*genetics/metabolism
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Cloning, Molecular
MH  - Gene Expression/genetics
MH  - Humans
MH  - Microsatellite Repeats/genetics
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - RNA, Messenger/metabolism
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 1999/03/02 03:03
MHDA- 2001/03/28 10:01
CRDT- 1999/03/02 03:03
PHST- 1999/03/02 03:03 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/03/02 03:03 [entrez]
AID - S0006-291X(99)90257-7 [pii]
AID - 10.1006/bbrc.1999.0257 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Feb 24;255(3):703-6. doi:
      10.1006/bbrc.1999.0257.