PMID- 10049591
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20071114
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 3
DP  - 1999 Feb 1
TI  - CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: 
      cDNA cloning, expression, and chromosomal localization.
PG  - 345-7
AB  - Sulfation is essential for the generation of functional vascular endothelial cell
      ligands for the leukocyte adhesion molecule, L-selectin. Therefore, human
      vascular endothelium cDNA libraries were screened to identify sulfotransferases
      homologous to chicken chondroitin 6-sulfotransferase (C6ST). Two
      sulfotransferases were identified: CHST2, a novel 530-amino-acid sulfotransferase
      with a carboxyl-terminal region that was 45 and 43% homologous with those of
      human and chicken C6ST, respectively, and CHST1, which was identical to human
      C6ST. Northern blot analysis showed that CHST2 was broadly expressed among
      tissues. The CHST2 gene mapped to human chromosome 3q24 close to 3q25. Thus, this
      study identified two sulfotransferases expressed by vascular endothelial cells
      that may contribute to the generation of L-selectin ligands during inflammatory
      responses.
FAU - Li, X
AU  - Li X
AD  - Department of Immunology, Duke University Medical Center, Durham, North Carolina 
      27710, USA.
FAU - Tedder, T F
AU  - Tedder TF
LA  - eng
SI  - GENBANK/AF083066
SI  - GENBANK/AF090137
GR  - AI26872/AI/NIAID NIH HHS/United States
GR  - CA54464/CA/NCI NIH HHS/United States
GR  - HL50985/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA Primers)
RN  - EC 2.8.2.- (Sulfotransferases)
RN  - EC 2.8.2.- (carbohydrate sulfotransferases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Brain Chemistry/genetics
MH  - Chickens
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA Primers
MH  - Databases, Factual
MH  - Endothelium, Vascular/*metabolism
MH  - Expressed Sequence Tags
MH  - Humans
MH  - Molecular Sequence Data
MH  - Sequence Homology, Amino Acid
MH  - Sulfotransferases/*genetics
MH  - Tissue Distribution
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0888-7543(98)95653-1 [pii]
AID - 10.1006/geno.1998.5653 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 1;55(3):345-7. doi: 10.1006/geno.1998.5653.