PMID- 10049590
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20141120
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 3
DP  - 1999 Feb 1
TI  - Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome
      17q23-q24.
PG  - 341-4
AB  - Conductin or Axil, an Axin homolog, plays an important role in the regulation of 
      beta-catenin stability in the Wnt signaling pathway. To facilitate the molecular 
      analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA
      contains a 2529-bp open reading frame and encodes a putative protein of 843 amino
      acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino
      acid identity. Several functional domains in this protein are highly conserved
      including the GRS (95.9%), GSK-3beta (96.3%), Dsh (98%), and beta-catenin (89.9%)
      domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome
      17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, 
      neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate
      involved in multiple tumor types.
FAU - Mai, M
AU  - Mai M
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation,
      Rochester, Minnesota 55905, USA.
FAU - Qian, C
AU  - Qian C
FAU - Yokomizo, A
AU  - Yokomizo A
FAU - Smith, D I
AU  - Smith DI
FAU - Liu, W
AU  - Liu W
LA  - eng
SI  - GENBANK/AF078165
GR  - CA48031/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (AXIN2 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Axin Protein)
RN  - 0 (Axin2 protein, rat)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Ctnnb1 protein, rat)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Wnt Proteins)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Axin Protein
MH  - *Carrier Proteins
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Cloning, Molecular
MH  - Cytoskeletal Proteins/*genetics
MH  - DNA Primers
MH  - Humans
MH  - Molecular Sequence Data
MH  - Proteins/*genetics
MH  - Proto-Oncogene Proteins/genetics
MH  - Rats
MH  - *Repressor Proteins
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
MH  - *Trans-Activators
MH  - Wnt Proteins
MH  - *Zebrafish Proteins
MH  - beta Catenin
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0888-7543(98)95650-6 [pii]
AID - 10.1006/geno.1998.5650 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 1;55(3):341-4. doi: 10.1006/geno.1998.5650.