PMID- 10049586
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20111117
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 3
DP  - 1999 Feb 1
TI  - Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous 
      genes in mouse and human.
PG  - 314-21
AB  - LRP7 (the HGMW-approved gene symbol for LR3) is a novel member of the low-density
      lipoprotein receptor (LDLR) family. The unique modular features in both its
      extracellular and its intracellular regions and functional analysis suggest it to
      be a multifunctional protein with mitogenic activity and potential ligand-induced
      signal transduction capability. We describe here the cloning of Lrp7, the
      orthologue of the human LRP7 gene, from a mouse liver cDNA library and its
      expression profile in mouse tissues and developmental stages. Lrp7 is highly
      homologous to the human sequence, with 95% identity at the amino acid level and a
      perfect conservation of all the recognizable functional domains. A 6-kb mRNA
      transcript could be detected in all the tissues examined, with the highest
      expression levels in liver, heart, and lung and the lowest levels in brain and
      spleen. A similar expression level of a smaller transcript (4.5 kb) was seen at
      the four embryonic stages examined. We mapped the Lrp 7 gene to mouse chromosome 
      19B and the LRP7 gene to human chromosome 11q13.4. The LRP7 gene was also
      localized by radiation hybrid mapping between markers D11S24270 and D11S1975.
FAU - Chen, D
AU  - Chen D
AD  - Bayer Research Center, Pharmaceutical Division, Bayer Corporation, West Haven,
      Connecticut 06516-4175, USA. david.chen.b@bayer.com
FAU - Lathrop, W
AU  - Lathrop W
FAU - Dong, Y
AU  - Dong Y
LA  - eng
SI  - GENBANK/AF077847
PT  - Journal Article
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (LDL-Receptor Related Proteins)
RN  - 0 (LRP5 protein, human)
RN  - 0 (Low Density Lipoprotein Receptor-Related Protein-5)
RN  - 0 (Lrp5 protein, mouse)
RN  - 0 (Receptors, LDL)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Gestational Age
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - LDL-Receptor Related Proteins
MH  - Liver/metabolism
MH  - Low Density Lipoprotein Receptor-Related Protein-5
MH  - Metaphase
MH  - Mice
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Physical Chromosome Mapping
MH  - Receptors, LDL/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0888-7543(98)95688-9 [pii]
AID - 10.1006/geno.1998.5688 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 1;55(3):314-21. doi: 10.1006/geno.1998.5688.