PMID- 10049584
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20190816
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 3
DP  - 1999 Feb 1
TI  - GPR56, a novel secretin-like human G-protein-coupled receptor gene.
PG  - 296-305
AB  - A novel gene product, GPR56, with homology to the seven transmembrane-domain
      receptor superfamily, has been cloned by PCR amplification using degenerate
      oligonucleotide primers and subsequent screening of a human heart cDNA library.
      The isolated 2.8-kb cDNA clone encodes a protein of 693 amino acids that shows
      highest identity (32%) to HE6, a member of a subclass of the class B
      secretin-like G-protein-coupled receptors. Northern analysis of various human
      tissues revealed a wide distribution of the transcript with highest levels found 
      in thyroid gland, brain, and heart. In situ hybridization analysis of human
      thyroid gland as well as rat heart and brain tissue confirms these results and
      identifies the hippocampus and hypothalamic nuclei as brain areas with
      particularly high expression of GPR56 mRNA. The high level of mRNA expression,
      its wide distribution, and the mucin-like extracellular domain of the receptor
      protein suggest a possible role for this receptor in cell-cell interaction
      processes. The human gene for GPR56 has been isolated and its exon-intron
      structure determined. The total length of the human GPR56 gene is approximately
      15 kb, and it consists of 13 exons. Fluorescence in situ hybridization, PCR
      analysis of somatic cell hybrids, and interspecific mouse backcross mapping have 
      localized the genes to human chromosome 16q13 and mouse chromosome 8.
FAU - Liu, M
AU  - Liu M
AD  - Garvan Institute of Medical Research, Neurobiology Program, St. Vincent's
      Hospital, Sydney, New South Wales, Australia.
FAU - Parker, R M
AU  - Parker RM
FAU - Darby, K
AU  - Darby K
FAU - Eyre, H J
AU  - Eyre HJ
FAU - Copeland, N G
AU  - Copeland NG
FAU - Crawford, J
AU  - Crawford J
FAU - Gilbert, D J
AU  - Gilbert DJ
FAU - Sutherland, G R
AU  - Sutherland GR
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Herzog, H
AU  - Herzog H
LA  - eng
SI  - GENBANK/AF106858
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (ADGRG1 protein, human)
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 1393-25-5 (Secretin)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 16/genetics
MH  - Crosses, Genetic
MH  - DNA Primers
MH  - Exons
MH  - GTP-Binding Proteins/genetics
MH  - Gene Library
MH  - Humans
MH  - Hypothalamus/cytology/ultrastructure
MH  - In Situ Hybridization
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Metaphase
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Models, Biological
MH  - Molecular Sequence Data
MH  - Myocardium/cytology/metabolism/ultrastructure
MH  - Rats
MH  - Receptors, Cell Surface/*genetics
MH  - *Receptors, G-Protein-Coupled
MH  - Secretin/*genetics
MH  - Thyroid Gland/cytology/metabolism
MH  - Tissue Distribution
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0888-7543(98)95644-0 [pii]
AID - 10.1006/geno.1998.5644 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 1;55(3):296-305. doi: 10.1006/geno.1998.5644.