PMID- 10049581
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20191210
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 3
DP  - 1999 Feb 1
TI  - Identification and characterization of the human homologue (RAI2) of a mouse
      retinoic acid-induced gene in Xp22.
PG  - 275-83
AB  - We have identified a novel human gene during studies of a 1.3-Mb region of Xp22
      between DXS418 and DXS999. A PAC contig spanning the region was constructed,
      sequenced, and analyzed by gene and exon prediction programs and by homology
      searches. Further investigation of predicted exons from PAC clone 389A20 led to
      the identification of a single-exon gene, designated RAI2 (retinoic acid-induced 
      2). RAI2 mapped 28 kb centromeric to marker DXS7996, between DXS7996 and DXS7997,
      and was transcribed from centromere to telomere. Northern blot analysis and
      reverse transcription-polymerase chain reaction analysis revealed expression of a
      2.5-kb transcript in four fetal tissues (brain, lung, kidney, and heart) and
      eight adult tissues (heart, brain, placenta, lung, skeletal muscle, kidney,
      pancreas, and retina) but not in fetal or adult liver. The 530-amino-acid protein
      (57 kDa predicted mass) displays 94% homology with a mouse retinoic acid-induced 
      gene product and contains a novel proline-rich (39%) domain of 68 amino acids.
      Retinoic acid is involved in vertebrate anteroposterior axis formation and
      cellular differentiation and has been shown to modulate gene expression
      controlling early embryonal development, suggesting a developmental role for
      RAI2. RAI2 remains a candidate gene for diseases mapping to the Xp22 region.
FAU - Walpole, S M
AU  - Walpole SM
AD  - Department of Medical Genetics, University of Cambridge, Cambridge Institute for 
      Medical Research, Addenbrooke's Hospital, United Kingdom.
FAU - Hiriyana, K T
AU  - Hiriyana KT
FAU - Nicolaou, A
AU  - Nicolaou A
FAU - Bingham, E L
AU  - Bingham EL
FAU - Durham, J
AU  - Durham J
FAU - Vaudin, M
AU  - Vaudin M
FAU - Ross, M T
AU  - Ross MT
FAU - Yates, J R
AU  - Yates JR
FAU - Sieving, P A
AU  - Sieving PA
FAU - Trump, D
AU  - Trump D
LA  - eng
SI  - GENBANK/AF136587
GR  - R01-EY10259/EY/NEI NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (DNA Primers)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
RN  - 0 (RAI2 protein, human)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - DNA Primers
MH  - Fetus/metabolism
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Proteins/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Tretinoin/pharmacology
MH  - X Chromosome/*genetics
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0888-7543(98)95667-1 [pii]
AID - 10.1006/geno.1998.5667 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 1;55(3):275-83. doi: 10.1006/geno.1998.5667.