PMID- 10049579
OWN - NLM
STAT- MEDLINE
DCOM- 19990524
LR  - 20091119
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 55
IP  - 3
DP  - 1999 Feb 1
TI  - Cloning and characterization of two cytoplasmic dynein intermediate chain genes
      in mouse and human.
PG  - 257-67
AB  - Cytoplasmic dynein is a large multisubunit microtubule-based motor protein, which
      mediates movement of numerous intracellular organelles. We report here the
      identification of the human homologue of cytoplasmic dynein intermediate chain 1 
      gene (DNCI1) located on human chromosome 7q21.3-q22.1. The mouse orthologue
      (Dnci1) was identified along with another highly related gene, Dnci2, and their
      RNA in situ expression patterns were examined during mouse embryogenesis. Dnci1
      was found to have a highly restricted expression domain in the developing
      forebrain as well as the peripheral nervous system (PNS), while Dnci2 displayed a
      broad expression profile throughout the entire central nervous system and most of
      the PNS. A dynamic expression profile was also found for Dnci2 in the developing 
      mouse limb bud. The data presented here provide a framework for the further
      analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human.
FAU - Crackower, M A
AU  - Crackower MA
AD  - Department of Molecular and Medical Genetics, University of Toronto, The Hospital
      for Sick Children, Ontario, Canada.
FAU - Sinasac, D S
AU  - Sinasac DS
FAU - Xia, J
AU  - Xia J
FAU - Motoyama, J
AU  - Motoyama J
FAU - Prochazka, M
AU  - Prochazka M
FAU - Rommens, J M
AU  - Rommens JM
FAU - Scherer, S W
AU  - Scherer SW
FAU - Tsui, L C
AU  - Tsui LC
LA  - eng
SI  - GENBANK/AF063228
SI  - GENBANK/AF063229
SI  - GENBANK/AF063230
SI  - GENBANK/AF063231
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - EC 3.6.4.2 (Dyneins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Chromosomes, Artificial, Yeast
MH  - Dyneins/*genetics/*metabolism/physiology
MH  - Embryo, Mammalian/metabolism
MH  - Embryonic and Fetal Development
MH  - Humans
MH  - In Situ Hybridization
MH  - Limb Buds/metabolism
MH  - Mice
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0888-7543(98)95665-8 [pii]
AID - 10.1006/geno.1998.5665 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 1;55(3):257-67. doi: 10.1006/geno.1998.5665.