PMID- 10049578
OWN - NLM
STAT- MEDLINE
DCOM- 19990420
LR  - 20041117
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 207
IP  - 1
DP  - 1999 Mar 1
TI  - Disrupted retinal development in the embryonic belly spot and tail mutant mouse.
PG  - 239-55
AB  - The Belly spot and tail (Bst) semidominant mutation, mapped to mouse Chromosome
      16, leads to developmental defects of the eye, skeleton, and coat pigmentation.
      In the eye, the mutant phenotype is characterized by the presence of retinal
      colobomas, a paucity of retinal ganglion cells, and axon misrouting. The severity
      of defects in the Bst/+ retina is variable among individuals and is often
      asymmetric. In order to determine the role of the Bst locus during retinal
      morphogenesis, we searched for the earliest observable defects in the developing 
      eye. We examined the retinas of Bst/+ and +/+ littermates from embryonic day 9.5 
      (E9.5) through E13.5 and measured retinal size, cell density, cell death, mitotic
      index, and cell birth index. We have found that development of the Bst/+ retina
      is notably dilatory by as early as E10.5. The affected retinas are smaller than
      their wildtype counterparts, and optic fissure fusion is delayed. In the mutant, 
      there is a marked lag in the exit of retinal cells from the mitotic cycle, even
      though there are no observable differences in the rate of cellular proliferation 
      or cell death between the two groups. We hypothesize that Bst regulates retinal
      cell differentiation and that variability of structural defects in the mutant,
      such as those affecting optic fissure fusion, is a reflection of the extent of
      developmental delay brought about by the Bst mutation.
CI  - Copyright 1999 Academic Press.
FAU - Tang, Q
AU  - Tang Q
AD  - Center for Neuroscience, University of Tennessee Memphis, 855 Monroe Avenue,
      Memphis, Tennessee, 38163, USA.
FAU - Rice, D S
AU  - Rice DS
FAU - Goldowitz, D
AU  - Goldowitz D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
SB  - IM
MH  - Animals
MH  - Cell Cycle/genetics
MH  - Cell Death/genetics
MH  - Cell Differentiation/genetics
MH  - Cell Division/genetics
MH  - Embryonic and Fetal Development
MH  - Eye/embryology/*growth & development
MH  - Eye Diseases/*genetics
MH  - Histocytochemistry
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Morphogenesis/genetics
MH  - Mutation/genetics
MH  - Phenotype
MH  - Retina/embryology/*growth & development
EDAT- 1999/03/02 00:00
MHDA- 1999/03/02 00:01
CRDT- 1999/03/02 00:00
PHST- 1999/03/02 00:00 [pubmed]
PHST- 1999/03/02 00:01 [medline]
PHST- 1999/03/02 00:00 [entrez]
AID - S0012-1606(98)99142-4 [pii]
AID - 10.1006/dbio.1998.9142 [doi]
PST - ppublish
SO  - Dev Biol. 1999 Mar 1;207(1):239-55. doi: 10.1006/dbio.1998.9142.