PMID- 10048338
OWN - NLM
STAT- MEDLINE
DCOM- 19990506
LR  - 20181113
IS  - 0961-8368 (Print)
IS  - 0961-8368 (Linking)
VI  - 8
IP  - 2
DP  - 1999 Feb
TI  - Identification of a novel domain shared by putative components of the endocytic
      and cytoskeletal machinery.
PG  - 435-8
AB  - We have identified a approximately 140 amino acid domain that is shared by a
      variety of proteins in budding and fission yeast, nematode, rat, mouse, frog,
      oat, and man. Typically, this domain is located within 20 residues of the
      N-terminus of the various proteins. The percent identity among the domains in the
      12 proteins ranges from 42 to 93%, with 16 absolutely conserved residues:
      N-x(11-13)-V-x2-A-T-x(34-36)-R-x(7-8)-W-R-x3-K-x12-G-x-E-x15
      -L-x11-12-D-x-G-R-x11-D-x7-R. Even though these proteins share little beyond
      their segment of homology, data are emerging that several of the proteins are
      involved in endocytosis and or regulation of cytoskeletal organization. We have
      named this protein segment the ENTH domain, for Epsin N-terminal Homology domain,
      and hypothesize that it is a candidate for binding specific ligands and/or
      enzymatic activity in the cell.
FAU - Kay, B K
AU  - Kay BK
AD  - Department of Pharmacology, University of Wisconsin-Madison, 53706-1532, USA.
      bkkay@facstaff.wisc.edu
FAU - Yamabhai, M
AU  - Yamabhai M
FAU - Wendland, B
AU  - Wendland B
FAU - Emr, S D
AU  - Emr SD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Protein Sci
JT  - Protein science : a publication of the Protein Society
JID - 9211750
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (Carrier Proteins)
RN  - 0 (Clathrin)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Vesicular Transport Proteins)
RN  - 0 (epsin)
SB  - IM
MH  - Adaptor Proteins, Vesicular Transport
MH  - Animals
MH  - Avena/genetics
MH  - Carrier Proteins/analysis
MH  - Clathrin/metabolism
MH  - Cytoskeletal Proteins/*analysis
MH  - Cytoskeleton/*physiology
MH  - Endocytosis/*physiology
MH  - Humans
MH  - Mice
MH  - Nematoda/genetics
MH  - Neuropeptides/analysis
MH  - *Protein Structure, Tertiary
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - *Vesicular Transport Proteins
MH  - Xenopus/genetics
MH  - Yeasts/genetics
PMC - PMC2144257
EDAT- 1999/02/27 00:00
MHDA- 1999/02/27 00:01
CRDT- 1999/02/27 00:00
PHST- 1999/02/27 00:00 [pubmed]
PHST- 1999/02/27 00:01 [medline]
PHST- 1999/02/27 00:00 [entrez]
AID - 10.1110/ps.8.2.435 [doi]
PST - ppublish
SO  - Protein Sci. 1999 Feb;8(2):435-8. doi: 10.1110/ps.8.2.435.