PMID- 10047538
OWN - NLM
STAT- MEDLINE
DCOM- 19990317
LR  - 20190915
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 11
IP  - 1
DP  - 1999 Feb
TI  - Genes regulating MHC class I processing of antigen.
PG  - 82-8
AB  - The principal pathway of antigen processing that is associated with MHC class I
      involves three main steps: cytosolic peptide generation, peptide transport into
      the endoplasmic reticulum and peptide assembly with class I molecules. Recent
      advances suggest that additional cytosolic proteases complement the proteasome as
      a source of antigenic peptides. Peptide assembly involves several novel cofactors
      - including the proteins tapasin and ERp57, which may be important for
      stabilisation of empty class I molecules as well as quality control after peptide
      binding. Finally, genetic evidence suggests an important influence of an
      unidentified gene, in the MHC complex, on MHC class I processing.
FAU - van Endert, P M
AU  - van Endert PM
AD  - INSERM U25 Hopital Necker, Paris, France. vanendert@necker.fr.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Antiporters)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Calreticulin)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (tapasin)
RN  - 145892-13-3 (TAP2 protein, human)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
RN  - EC 5.- (Isomerases)
RN  - EC 5.3.4.1 (Protein Disulfide-Isomerases)
RN  - EC 5.3.4.1. (PDIA3 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/genetics/immunology
MH  - Animals
MH  - *Antigen Presentation
MH  - Antiporters/genetics/immunology
MH  - Calcium-Binding Proteins/genetics/immunology
MH  - Calreticulin
MH  - Cysteine Endopeptidases/genetics/immunology
MH  - Genes/genetics/*immunology
MH  - Heat-Shock Proteins/genetics/immunology
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Immunoglobulins/genetics/immunology
MH  - Isomerases/genetics/immunology
MH  - Membrane Transport Proteins
MH  - Multienzyme Complexes/genetics/immunology
MH  - Proteasome Endopeptidase Complex
MH  - Protein Disulfide-Isomerases
MH  - Ribonucleoproteins/genetics/immunology
RF  - 64
EDAT- 1999/02/27 00:00
MHDA- 1999/02/27 00:01
CRDT- 1999/02/27 00:00
PHST- 1999/02/27 00:00 [pubmed]
PHST- 1999/02/27 00:01 [medline]
PHST- 1999/02/27 00:00 [entrez]
AID - S0952-7915(99)80015-6 [pii]
AID - 10.1016/s0952-7915(99)80015-6 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 1999 Feb;11(1):82-8. doi: 10.1016/s0952-7915(99)80015-6.