PMID- 10047537
OWN - NLM
STAT- MEDLINE
DCOM- 19990317
LR  - 20190915
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 11
IP  - 1
DP  - 1999 Feb
TI  - Antigen presentation by MHC class I and its regulation by interferon gamma.
PG  - 76-81
AB  - Antigen processing by MHC class I molecules begins with the generation of
      peptides by proteolytic breakdown of proteins. IFN-gamma upregulates gene
      expression of several proteasomal subunits as well as the proteasome regulator
      PA28; this implicated their role in antigen degradation. Crystallographic,
      mutational and biochemical studies contributed to our understanding of the basic 
      principles of proteasomal protein degradation and the consequences of IFN-gamma
      induction for proteasome function. In addition, nonproteasomal mechanisms seem to
      be involved in antigen degradation. Leucine aminopeptidase, which is also
      upregulated by IFN-gamma, was shown to collaborate with the proteasome for
      epitope production and unknown proteases seem to compensate for the loss of
      proteasomal degradation in the presence of proteasome inhibitors. Thus, a rather 
      complex picture emerges for the rules governing peptide production in the
      presence or absence of IFN-gamma.
FAU - Fruh, K
AU  - Fruh K
AD  - The R. W. Johnson Pharmaceutical Research Institute, General Atomics Court, San
      Diego, CA 92121, USA. kfrueh@prius.jnj.com.
FAU - Yang, Y
AU  - Yang Y
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Multienzyme Complexes)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Antigen Presentation/*drug effects
MH  - Cysteine Endopeptidases/chemistry/drug effects/immunology
MH  - Histocompatibility Antigens Class I/*drug effects/immunology
MH  - Humans
MH  - Interferon-gamma/*pharmacology
MH  - Multienzyme Complexes/chemistry/drug effects/immunology
MH  - Proteasome Endopeptidase Complex
RF  - 52
EDAT- 1999/02/27 00:00
MHDA- 1999/02/27 00:01
CRDT- 1999/02/27 00:00
PHST- 1999/02/27 00:00 [pubmed]
PHST- 1999/02/27 00:01 [medline]
PHST- 1999/02/27 00:00 [entrez]
AID - S0952-7915(99)80014-4 [pii]
AID - 10.1016/s0952-7915(99)80014-4 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 1999 Feb;11(1):76-81. doi: 10.1016/s0952-7915(99)80014-4.