PMID- 10047530
OWN - NLM
STAT- MEDLINE
DCOM- 19990316
LR  - 20190915
IS  - 0955-0674 (Print)
IS  - 0955-0674 (Linking)
VI  - 11
IP  - 1
DP  - 1999 Feb
TI  - Functions of gelsolin: motility, signaling, apoptosis, cancer.
PG  - 103-8
AB  - Several new members of the gelsolin family have been discovered in the past year.
      Determination of the structure of gelsolin and identification of lysophosphatidic
      acid as a negative regulator provide novel functional insights. Gelsolin is an
      obligate downstream effector of Rac for motility in dermal fibroblasts, regulates
      phosphoinositide signaling pathways and ion channel function in vivo, and acts as
      both a regulator and effector of apoptosis.
FAU - Kwiatkowski, D J
AU  - Kwiatkowski DJ
AD  - Genetics Laboratory Hematology Division Brigham and Women's Hospital 221 Longwood
      Avenue Boston MA 02115 USA. kwiatkowski@calvin.bwh.harvard.edu
LA  - eng
GR  - HL48743/HL/NHLBI NIH HHS/United States
GR  - HL54188/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Curr Opin Cell Biol
JT  - Current opinion in cell biology
JID - 8913428
RN  - 0 (AVIL protein, human)
RN  - 0 (Gelsolin)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (SVIL protein, human)
RN  - 0 (Svil protein, mouse)
RN  - 0 (scinderin)
SB  - IM
MH  - Amyloidosis/metabolism
MH  - Animals
MH  - Apoptosis/physiology
MH  - Cell Movement/physiology
MH  - Gelsolin/*chemistry/*physiology
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Ion Channels/metabolism
MH  - Lipid Metabolism
MH  - Membrane Proteins/metabolism
MH  - Mice
MH  - Microfilament Proteins/metabolism
RF  - 57
EDAT- 1999/02/27 00:00
MHDA- 1999/02/27 00:01
CRDT- 1999/02/27 00:00
PHST- 1999/02/27 00:00 [pubmed]
PHST- 1999/02/27 00:01 [medline]
PHST- 1999/02/27 00:00 [entrez]
AID - S0955-0674(99)80012-X [pii]
AID - 10.1016/s0955-0674(99)80012-x [doi]
PST - ppublish
SO  - Curr Opin Cell Biol. 1999 Feb;11(1):103-8. doi: 10.1016/s0955-0674(99)80012-x.