PMID- 10037799
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20190508
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 144
IP  - 4
DP  - 1999 Feb 22
TI  - LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor
      for hyaluronan.
PG  - 789-801
AB  - The extracellular matrix glycosaminoglycan hyaluronan (HA) is an abundant
      component of skin and mesenchymal tissues where it facilitates cell migration
      during wound healing, inflammation, and embryonic morphogenesis. Both during
      normal tissue homeostasis and particularly after tissue injury, HA is mobilized
      from these sites through lymphatic vessels to the lymph nodes where it is
      degraded before entering the circulation for rapid uptake by the liver.
      Currently, however, the identities of HA binding molecules which control this
      pathway are unknown. Here we describe the first such molecule, LYVE-1, which we
      have identified as a major receptor for HA on the lymph vessel wall. The deduced 
      amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane
      polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular 
      domain containing a single Link module the prototypic HA binding domain of the
      Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and
      immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on 
      the luminal face of the lymph vessel wall and is completely absent from blood
      vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be
      characterized and is a uniquely powerful marker for lymph vessels themselves.
FAU - Banerji, S
AU  - Banerji S
AD  - University of Oxford, Molecular Immunology Group, Nuffield Department of
      Medicine, John Radcliff Hospital, Headington, Oxford OX3 9DU, United Kingdom.
FAU - Ni, J
AU  - Ni J
FAU - Wang, S X
AU  - Wang SX
FAU - Clasper, S
AU  - Clasper S
FAU - Su, J
AU  - Su J
FAU - Tammi, R
AU  - Tammi R
FAU - Jones, M
AU  - Jones M
FAU - Jackson, D G
AU  - Jackson DG
LA  - eng
SI  - GENBANK/AF118108
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Glycoproteins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (LYVE1 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vesicular Transport Proteins)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - COS Cells
MH  - Cell Membrane/metabolism
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Glycoproteins/chemistry/genetics/*metabolism
MH  - Humans
MH  - Hyaluronan Receptors/chemistry/genetics/*metabolism
MH  - Hyaluronic Acid/*metabolism
MH  - Lymphatic System/*metabolism
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Transfection
MH  - Vesicular Transport Proteins
PMC - PMC2132933
EDAT- 1999/02/26 03:06
MHDA- 2000/04/29 09:00
CRDT- 1999/02/26 03:06
PHST- 1999/02/26 03:06 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 1999/02/26 03:06 [entrez]
AID - 10.1083/jcb.144.4.789 [doi]
PST - ppublish
SO  - J Cell Biol. 1999 Feb 22;144(4):789-801. doi: 10.1083/jcb.144.4.789.