PMID- 10037736
OWN - NLM
STAT- MEDLINE
DCOM- 19990330
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 10
DP  - 1999 Mar 5
TI  - Molecular cloning and functional characterization of a new Cap'n' collar family
      transcription factor Nrf3.
PG  - 6443-52
AB  - The NF-E2-binding sites or Maf recognition elements (MARE) are essential
      cis-acting elements in the regulatory regions of erythroid-specific genes
      recognized by the erythroid transcription factor NF-E2, composed of p45 and MafK.
      Recently, two p45-related factors Nrf1 and Nrf2 were isolated, and they are now
      collectively grouped as the Cap'n' collar (CNC) family. CNC factors bind to MARE 
      through heterodimer formation with small Maf proteins. We report here the
      identification and characterization of a novel CNC factor, Nrf3, encoding a
      predicted 73-kDa protein with a basic region-leucine zipper domain highly
      homologous to those of other CNC proteins. In vitro and in vivo analyses showed
      that Nrf3 can heterodimerize with MafK and that this complex binds to the MARE in
      the chicken beta-globin enhancer and can activate transcription. Nrf3 mRNA is
      highly expressed in human placenta and B cell and monocyte lineage. Chromosomal
      localization of human Nrf3 is 7p14-15, which lies near the hoxA gene locus. As
      the genetic loci of p45, nrf1, and nrf2 have been mapped close to those of hoxC, 
      hoxB, and hoxD, respectively, the present study strongly argues for the idea that
      a single ancestral gene for the CNC family members may have been localized near
      the ancestral Hox cluster and have diverged to give rise to four closely related 
      CNC factors through chromosome duplication.
FAU - Kobayashi, A
AU  - Kobayashi A
AD  - Department of Biochemistry, Tohoku University School of Medicine, 2-1
      Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. akira-k@mail.cc.tohoku.ac.jp
FAU - Ito, E
AU  - Ito E
FAU - Toki, T
AU  - Toki T
FAU - Kogame, K
AU  - Kogame K
FAU - Takahashi, S
AU  - Takahashi S
FAU - Igarashi, K
AU  - Igarashi K
FAU - Hayashi, N
AU  - Hayashi N
FAU - Yamamoto, M
AU  - Yamamoto M
LA  - eng
SI  - GENBANK/AB010812
SI  - GENBANK/AB013852
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Erythroid-Specific DNA-Binding Factors)
RN  - 0 (MAFK protein, human)
RN  - 0 (MafK Transcription Factor)
RN  - 0 (Mafk protein, mouse)
RN  - 0 (NF-E2 Transcription Factor)
RN  - 0 (NF-E2 Transcription Factor, p45 Subunit)
RN  - 0 (NFE2 protein, human)
RN  - 0 (NFE2L3 protein, human)
RN  - 0 (Nfe2 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Basic-Leucine Zipper Transcription Factors
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/genetics
MH  - Erythroid-Specific DNA-Binding Factors
MH  - HeLa Cells
MH  - Humans
MH  - MafK Transcription Factor
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-E2 Transcription Factor
MH  - NF-E2 Transcription Factor, p45 Subunit
MH  - Nuclear Proteins/*genetics
MH  - RNA, Messenger/analysis/genetics
MH  - Sequence Alignment
MH  - Transcription Factors/*genetics
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - 10.1074/jbc.274.10.6443 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Mar 5;274(10):6443-52. doi: 10.1074/jbc.274.10.6443.