PMID- 10037686
OWN - NLM
STAT- MEDLINE
DCOM- 19990330
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 10
DP  - 1999 Mar 5
TI  - Identification of a novel activation-inducible protein of the tumor necrosis
      factor receptor superfamily and its ligand.
PG  - 6056-61
AB  - Among members of the tumor necrosis factor receptor (TNFR) superfamily, 4-1BB,
      CD27, and glucocorticoid-induced tumor necrosis factor receptor family-related
      gene (GITR) share a striking homology in the cytoplasmic domain. Here we report
      the identification of a new member, activation-inducible TNFR family member
      (AITR), which belongs to this subfamily, and its ligand. The receptor is
      expressed in lymph node and peripheral blood leukocytes, and its expression is
      up-regulated in human peripheral mononuclear cells mainly after stimulation with 
      anti-CD3/CD28 monoclonal antibodies or phorbol 12-myristate 13-acetate/ionomycin.
      AITR associates with TRAF1 (TNF receptor-associated factor 1), TRAF2, and TRAF3, 
      and induces nuclear factor (NF)-kappaB activation via TRAF2. The ligand for AITR 
      (AITRL) was found to be an undescribed member of the TNF family, which is
      expressed in endothelial cells. Thus, AITR and AITRL seem to be important for
      interactions between activated T lymphocytes and endothelial cells.
FAU - Kwon, B
AU  - Kwon B
AD  - Department of Microbiology and Immunology and the Walther Oncology Center,
      Indiana University School of Medicine and the Walther Cancer Institute,
      Indianapolis, Indiana 46202, USA.
FAU - Yu, K Y
AU  - Yu KY
FAU - Ni, J
AU  - Ni J
FAU - Yu, G L
AU  - Yu GL
FAU - Jang, I K
AU  - Jang IK
FAU - Kim, Y J
AU  - Kim YJ
FAU - Xing, L
AU  - Xing L
FAU - Liu, D
AU  - Liu D
FAU - Wang, S X
AU  - Wang SX
FAU - Kwon, B S
AU  - Kwon BS
LA  - eng
SI  - GENBANK/AF117297
SI  - GENBANK/AF117713
GR  - AI28125/AI/NIAID NIH HHS/United States
GR  - DE12156/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA, Complementary)
RN  - 0 (Ligands)
RN  - 0 (Receptors, Tumor Necrosis Factor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary/analysis/genetics
MH  - *Genome, Human
MH  - Humans
MH  - Leukocytes/metabolism
MH  - Ligands
MH  - Lymph Nodes/metabolism
MH  - Molecular Sequence Data
MH  - Receptors, Tumor Necrosis Factor/biosynthesis/*genetics
MH  - Sequence Alignment
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - 10.1074/jbc.274.10.6056 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Mar 5;274(10):6056-61. doi: 10.1074/jbc.274.10.6056.