PMID- 10037471
OWN - NLM
STAT- MEDLINE
DCOM- 19990318
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 72
IP  - 3
DP  - 1999 Mar
TI  - Presenilins interact with armadillo proteins including neural-specific
      plakophilin-related protein and beta-catenin.
PG  - 999-1008
AB  - Missense substitutions in the presenilin 1 (PS1) and presenilin 2 (PS2) proteins 
      are associated with early-onset familial Alzheimer's disease. We have used
      yeast-two-hybrid and coimmunoprecipitation methods to show that the large
      cytoplasmic loop domains of PS1 and PS2 interact specifically with three members 
      of the armadillo protein family, including beta-catenin, p0071, and a novel
      neuronal-specific armadillo protein--neural plakophilin-related armadillo protein
      (NPRAP). The PS1:NPRAP interaction occurs between the arm repeats of NPRAP and
      residues 372-399 at the C-terminal end of the large cytoplasmic loop of PS1. The 
      latter residues contain a single arm-like domain and are highly conserved in the 
      presenilins, suggesting that they form a functional armadillo protein binding
      site for the presenilins.
FAU - Levesque, G
AU  - Levesque G
AD  - Centre for Research in Neurodegenerative Diseases, Department of Medicine
      (Neurology), University of Toronto, and Toronto Hospital, Ontario, Canada.
FAU - Yu, G
AU  - Yu G
FAU - Nishimura, M
AU  - Nishimura M
FAU - Zhang, D M
AU  - Zhang DM
FAU - Levesque, L
AU  - Levesque L
FAU - Yu, H
AU  - Yu H
FAU - Xu, D
AU  - Xu D
FAU - Liang, Y
AU  - Liang Y
FAU - Rogaeva, E
AU  - Rogaeva E
FAU - Ikeda, M
AU  - Ikeda M
FAU - Duthie, M
AU  - Duthie M
FAU - Murgolo, N
AU  - Murgolo N
FAU - Wang, L
AU  - Wang L
FAU - VanderVere, P
AU  - VanderVere P
FAU - Bayne, M L
AU  - Bayne ML
FAU - Strader, C D
AU  - Strader CD
FAU - Rommens, J M
AU  - Rommens JM
FAU - Fraser, P E
AU  - Fraser PE
FAU - St George-Hyslop, P
AU  - St George-Hyslop P
LA  - eng
GR  - 37920/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Armadillo Domain Proteins)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (CTNNB1 protein, mouse)
RN  - 0 (Catenins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PKP4 protein, human)
RN  - 0 (PSEN1 protein, human)
RN  - 0 (PSEN2 protein, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (Plakophilins)
RN  - 0 (Presenilin-1)
RN  - 0 (Presenilin-2)
RN  - 0 (Trans-Activators)
RN  - 0 (beta Catenin)
RN  - 0 (delta catenin)
SB  - IM
MH  - Alzheimer Disease/genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - Armadillo Domain Proteins
MH  - Catenins
MH  - Cell Adhesion Molecules
MH  - Cells, Cultured
MH  - Chromatography, Affinity
MH  - Cytoskeletal Proteins/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Membrane Proteins/genetics/*metabolism
MH  - Mice
MH  - Microscopy, Confocal
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Phosphoproteins
MH  - Plakophilins
MH  - Precipitin Tests
MH  - Presenilin-1
MH  - Presenilin-2
MH  - Protein Binding
MH  - *Trans-Activators
MH  - Transfection
MH  - beta Catenin
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - 10.1046/j.1471-4159.1999.0720999.x [doi]
PST - ppublish
SO  - J Neurochem. 1999 Mar;72(3):999-1008. doi: 10.1046/j.1471-4159.1999.0720999.x.