PMID- 10036234
OWN - NLM
STAT- MEDLINE
DCOM- 19990504
LR  - 20051117
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 112 ( Pt 6)
DP  - 1999 Mar
TI  - Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi
      network.
PG  - 845-54
AB  - SNARE proteins are known to play a role in regulating intracellular protein
      transport between donor and target membranes. This docking and fusion process
      involves the interaction of specific vesicle-SNAREs (e.g. VAMP) with specific
      cognate target-SNAREs (e.g. syntaxin and SNAP-23). Using human SNAP-23 as the
      bait in a yeast two-hybrid screen of a human B-lymphocyte cDNA library, we have
      identified the 287-amino-acid SNARE protein syntaxin 11. Like other syntaxin
      family members, syntaxin 11 binds to the SNARE proteins VAMP and SNAP-23 in vitro
      and also exists in a complex with SNAP-23 in transfected HeLa cells and in native
      human B lymphocytes. Unlike other syntaxin family members, no obvious
      transmembrane domain is present in syntaxin 11. Nevertheless, syntaxin 11 is
      predominantly membrane-associated and colocalizes with the mannose 6-phosphate
      receptor on late endosomes and the trans-Golgi network. These data suggest that
      syntaxin 11 is a SNARE that acts to regulate protein transport between late
      endosomes and the trans-Golgi network in mammalian cells.
FAU - Valdez, A C
AU  - Valdez AC
AD  - Experimental Immunology Branch, National Cancer Institute, National Institutes of
      Health, Bethesda, MD 20892, USA.
FAU - Cabaniols, J P
AU  - Cabaniols JP
FAU - Brown, M J
AU  - Brown MJ
FAU - Roche, P A
AU  - Roche PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Qa-SNARE Proteins)
RN  - 0 (Qb-SNARE Proteins)
RN  - 0 (Qc-SNARE Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (SNAP23 protein, human)
SB  - IM
MH  - Alternative Splicing
MH  - B-Lymphocytes
MH  - Carrier Proteins/*analysis/biosynthesis
MH  - Cell Fractionation
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Endosomes/*ultrastructure
MH  - Female
MH  - Gene Library
MH  - Golgi Apparatus/*ultrastructure
MH  - HeLa Cells
MH  - Humans
MH  - Intracellular Membranes/ultrastructure
MH  - Membrane Proteins/*analysis/biosynthesis/*genetics
MH  - Organ Specificity
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - Qa-SNARE Proteins
MH  - Qb-SNARE Proteins
MH  - Qc-SNARE Proteins
MH  - Recombinant Proteins/biosynthesis
MH  - Transcription, Genetic
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
PST - ppublish
SO  - J Cell Sci. 1999 Mar;112 ( Pt 6):845-54.