PMID- 10036192
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20191231
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 1
DP  - 1999 Feb 15
TI  - DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to
      doublecortin (DCX).
PG  - 121-6
AB  - Mutations in the human doublecortin (DCX), a brain-specific putative signaling
      protein, cause X-linked lissencephaly and subcortical band heterotopia. A
      predicted 740-amino-acid protein from human brain has two distinct regions, an
      N-terminal 345-amino-acid region 78% similar to the DCX protein and a C-terminal 
      427-amino-acid region that contains two transmembrane domains and is 98%
      homologous to a rat Ca2+/calmodulin-dependent protein kinase. We have designated 
      this protein DCAMKL1. It maps to chromosome 13q12.3-q13, within a 540-kb YAC
      clone containing markers D13S805 and D13S1164. Northern analysis detected three
      major transcript isoforms of the DCAMKL1 gene expressed differentially and
      predominantly in human fetal and adult brain and during mouse embryogenesis
      (11-17 dpc). These results and its homology with the DCX and Ca2+/calmodulin
      dependent kinase proteins suggest a likely role for DCAMKL1 transmembrane protein
      in developing and adult brain, possibly in a pathway of cortical development.
CI  - Copyright 1999 Academic Press.
FAU - Sossey-Alaoui, K
AU  - Sossey-Alaoui K
AD  - J. C. Self Research Institute of Human Genetics, Greenwood Genetic Center,
      Greenwood, South Carolina, 29646, USA.
FAU - Srivastava, A K
AU  - Srivastava AK
LA  - eng
GR  - R01-NS35515/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (doublecortin protein)
RN  - EC 2.7.1.- (Dcamkl1 protein, mouse)
RN  - EC 2.7.1.- (Dclk1 protein, rat)
RN  - EC 2.7.1.11 (DCLK1 protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain Chemistry/*genetics
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*genetics
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - *Microtubule-Associated Proteins
MH  - Molecular Sequence Data
MH  - Neuropeptides/*genetics
MH  - Protein-Serine-Threonine Kinases/genetics
MH  - Rats
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Time Factors
MH  - Tissue Distribution
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - S0888-7543(98)95718-4 [pii]
AID - 10.1006/geno.1998.5718 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 15;56(1):121-6. doi: 10.1006/geno.1998.5718.