PMID- 10036186
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20071114
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 1
DP  - 1999 Feb 15
TI  - A gene upregulated in the acoustically damaged chick basilar papilla encodes a
      novel WD40 repeat protein.
PG  - 59-69
AB  - The chick WDR1 gene is expressed at higher levels in the chick basilar papilla
      after acoustic overstimulation. The 3.3-kb WDR1 cDNA encodes a novel 67-kDa
      protein containing nine WD40 repeats, motifs that mediate protein-protein
      interactions. The predicted WDR1 protein has high sequence identity to
      WD40-repeat proteins in budding yeast (Saccharomyces cerevisiae), two slime molds
      (Dictyostelium discoideum and Physarum polycephalum), and the roundworm
      (Caenorhabditis elegans). The yeast and P. polycephalum proteins bind actin,
      suggesting that the novel chick protein may be an actin-binding protein. Sequence
      database comparisons identified mouse and human cDNAs with high sequence identity
      to the chick WDR1 cDNA. The mouse Wdr1 and human WDR1 proteins showed 95%
      sequence identity to each other and 86% identity to the chick WDR1 protein.
      Northern blot analysis of total RNA from the chick basilar papilla after noise
      trauma revealed increased levels of a 3.1-kb transcript in the lesioned area. The
      WDR1 gene was mapped to human chromosome 4, between 22 and 24 cM from the
      telomere of 4p.
CI  - Copyright 1999 Academic Press.
FAU - Adler, H J
AU  - Adler HJ
AD  - Department of Otolaryngology/Head-Neck Surgery, University of Michigan, Ann
      Arbor, Michigan, 48109, USA.
FAU - Winnicki, R S
AU  - Winnicki RS
FAU - Gong, T W
AU  - Gong TW
FAU - Lomax, M I
AU  - Lomax MI
LA  - eng
SI  - GENBANK/AF020054
SI  - GENBANK/AF020055
SI  - GENBANK/AF020056
SI  - GENBANK/AF020260
GR  - DC02492/DC/NIDCD NIH HHS/United States
GR  - P01 DC02982/DC/NIDCD NIH HHS/United States
GR  - R01 DC02492/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Actins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (WDR1 protein, human)
SB  - IM
MH  - Actins/genetics
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Basilar Membrane/*metabolism
MH  - Chickens/*genetics/physiology
MH  - Chromosomes, Human, Pair 4/genetics
MH  - Gene Expression
MH  - Hearing Loss, Noise-Induced/genetics
MH  - Humans
MH  - Mice
MH  - Microfilament Proteins/*genetics
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - Restriction Mapping
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - S0888-7543(98)95672-5 [pii]
AID - 10.1006/geno.1998.5672 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 15;56(1):59-69. doi: 10.1006/geno.1998.5672.