PMID- 10036185
OWN - NLM
STAT- MEDLINE
DCOM- 19990505
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 56
IP  - 1
DP  - 1999 Feb 15
TI  - The murine Bin1 gene functions early in myogenesis and defines a new region of
      synteny between mouse chromosome 18 and human chromosome 2.
PG  - 51-8
AB  - We cloned and functionally characterized the murine Bin1 gene as a first step to 
      investigate its physiological roles in differentiation, apoptosis, and
      tumorigenesis. The exon-intron organization of the >/=55-kb gene is similar to
      that of the human gene. Consistent with a role for Bin1 in apoptosis, the
      promoter included a functional consensus motif for activation by NF-kappaB, an
      important regulator of cell death. A muscle regulatory module defined in the
      human promoter that includes a consensus recognition site for myoD family
      proteins was not conserved in the mouse promoter. However, Bin1 is upregulated in
      embryonic development by E10.5 in myotomes, the progenitors of skeletal muscle,
      supporting a role in myogenesis and suggesting that the mouse and human genes may
      be controlled somewhat differently during development. In C2C12 myoblasts
      antisense Bin1 prevents induction of the cell cycle kinase inhibitor p21WAF1,
      suggesting that it acts at an early time during the muscle differentiation
      program. Interspecific mouse backcross mapping located the Bin1 locus between
      Mep1b and Apc on chromosome 18. Since the human gene was mapped previously to
      chromosome 2q14, the location of Bin1 defines a previously unrecognized region of
      synteny between human chromosome 2 and mouse chromosome 18.
CI  - Copyright 1999 Academic Press.
FAU - Mao, N C
AU  - Mao NC
AD  - The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, 19104, USA.
FAU - Steingrimsson, E
AU  - Steingrimsson E
FAU - DuHadaway, J
AU  - DuHadaway J
FAU - Wasserman, W
AU  - Wasserman W
FAU - Ruiz, J C
AU  - Ruiz JC
FAU - Copeland, N G
AU  - Copeland NG
FAU - Jenkins, N A
AU  - Jenkins NA
FAU - Prendergast, G C
AU  - Prendergast GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (BIN1 protein, human)
RN  - 0 (Bin1 protein, mouse)
RN  - 0 (Carrier Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Tumor Suppressor Proteins)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Apoptosis/genetics
MH  - Base Sequence
MH  - Carrier Proteins/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 2/*genetics
MH  - Exons
MH  - Humans
MH  - Introns
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Muscle Development
MH  - Muscle, Skeletal/anatomy & histology/*growth & development
MH  - *Nerve Tissue Proteins
MH  - Nuclear Proteins/*genetics
MH  - Physical Chromosome Mapping
MH  - Restriction Mapping
MH  - Sequence Homology, Nucleic Acid
MH  - *Tumor Suppressor Proteins
EDAT- 1999/02/26 00:00
MHDA- 1999/02/26 00:01
CRDT- 1999/02/26 00:00
PHST- 1999/02/26 00:00 [pubmed]
PHST- 1999/02/26 00:01 [medline]
PHST- 1999/02/26 00:00 [entrez]
AID - S0888-7543(98)95709-3 [pii]
AID - 10.1006/geno.1998.5709 [doi]
PST - ppublish
SO  - Genomics. 1999 Feb 15;56(1):51-8. doi: 10.1006/geno.1998.5709.