PMID- 10029069
OWN - NLM
STAT- MEDLINE
DCOM- 19990304
LR  - 20180227
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 59
IP  - 4
DP  - 1999 Feb 15
TI  - hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is
      expressed during spermatogenesis.
PG  - 816-22
AB  - MutS homologues have been identified in nearly all organisms examined to date.
      They play essential roles in maintaining mitotic genetic fidelity and meiotic
      segregation fidelity. MutS homologues appear to function as a molecular switch
      that signals genomic manipulation events. Here we describe the identification of 
      the human homologue of the Saccharomyces cerevisiae MSH5, which is known to
      participate in meiotic segregation fidelity and crossing-over. The human MSH5
      (hMSH5) was localized to chromosome 6p22-21 and appears to play a role in meiosis
      because expression is induced during spermatogenesis between the late primary
      spermatocytes and the elongated spermatid phase. hMSH5 interacts specifically
      with hMSH4, confirming the generality of functional heterodimeric interactions in
      the eukaryotic MutS homologue, which also includes hMSH2-hMSH3 and hMSH2-hMSH6.
FAU - Bocker, T
AU  - Bocker T
AD  - Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas
      Jefferson University and Medical College, Philadelphia, Pennsylvania 19107, USA.
FAU - Barusevicius, A
AU  - Barusevicius A
FAU - Snowden, T
AU  - Snowden T
FAU - Rasio, D
AU  - Rasio D
FAU - Guerrette, S
AU  - Guerrette S
FAU - Robbins, D
AU  - Robbins D
FAU - Schmidt, C
AU  - Schmidt C
FAU - Burczak, J
AU  - Burczak J
FAU - Croce, C M
AU  - Croce CM
FAU - Copeland, T
AU  - Copeland T
FAU - Kovatich, A J
AU  - Kovatich AJ
FAU - Fishel, R
AU  - Fishel R
LA  - eng
SI  - GENBANK/AF034759
GR  - R01 CA067007/CA/NCI NIH HHS/United States
GR  - CA56542/CA/NCI NIH HHS/United States
GR  - CA67007/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Fungal Proteins)
RN  - 0 (MSH4 protein, S cerevisiae)
RN  - 0 (MSH5 protein, S cerevisiae)
RN  - 0 (Saccharomyces cerevisiae Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *DNA-Binding Proteins
MH  - Fungal Proteins/*analysis/*chemistry/genetics
MH  - Humans
MH  - Male
MH  - Meiosis
MH  - Molecular Sequence Data
MH  - *Saccharomyces cerevisiae Proteins
MH  - *Spermatogenesis
EDAT- 1999/02/24 00:00
MHDA- 1999/02/24 00:01
CRDT- 1999/02/24 00:00
PHST- 1999/02/24 00:00 [pubmed]
PHST- 1999/02/24 00:01 [medline]
PHST- 1999/02/24 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1999 Feb 15;59(4):816-22.