PMID- 10027300
OWN - NLM
STAT- MEDLINE
DCOM- 19990316
LR  - 20200619
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 22
IP  - 1
DP  - 1999 Jan
TI  - Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.
PG  - 179-87
AB  - Synaptic clustering of neurotransmitter receptors is crucial for efficient signal
      transduction and integration in neurons. PDZ domain-containing proteins such as
      PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors 
      and are thought to be important in the targeting and anchoring of receptors to
      specific synapses. Here, we show that PICK1 (protein interacting with C kinase), 
      a PDZ domain-containing protein, interacts with the C termini of
      alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptors in
      vitro and in vivo. In neurons, PICK1 specifically colocalizes with AMPA receptors
      at excitatory synapses. Furthermore, PICK1 induces clustering of AMPA receptors
      in heterologous expression systems. These results suggest that PICK1 may play an 
      important role in the modulation of synaptic transmission by regulating the
      synaptic targeting of AMPA receptors.
FAU - Xia, J
AU  - Xia J
AD  - Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins
      University School of Medicine, Baltimore, Maryland 21205, USA.
FAU - Zhang, X
AU  - Zhang X
FAU - Staudinger, J
AU  - Staudinger J
FAU - Huganir, R L
AU  - Huganir RL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Isoenzymes)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PICK1 protein, rat)
RN  - 0 (Receptors, AMPA)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.13 (Protein Kinase C-alpha)
SB  - IM
MH  - Aging/metabolism
MH  - Amino Acid Sequence/genetics
MH  - Animals
MH  - Carrier Proteins/*genetics/metabolism/*physiology
MH  - Cytoskeletal Proteins
MH  - Isoenzymes/metabolism
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*genetics/metabolism/*physiology
MH  - Protein Kinase C/metabolism
MH  - Protein Kinase C-alpha
MH  - Rats
MH  - Receptor Aggregation/*physiology
MH  - Receptors, AMPA/metabolism/*physiology
MH  - Subcellular Fractions/metabolism
MH  - Synapses/metabolism/*physiology
MH  - Tissue Distribution
EDAT- 1999/02/23 00:00
MHDA- 1999/02/23 00:01
CRDT- 1999/02/23 00:00
PHST- 1999/02/23 00:00 [pubmed]
PHST- 1999/02/23 00:01 [medline]
PHST- 1999/02/23 00:00 [entrez]
AID - S0896-6273(00)80689-3 [pii]
AID - 10.1016/s0896-6273(00)80689-3 [doi]
PST - ppublish
SO  - Neuron. 1999 Jan;22(1):179-87. doi: 10.1016/s0896-6273(00)80689-3.