PMID- 10025957
OWN - NLM
STAT- MEDLINE
DCOM- 19990311
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 443
IP  - 3
DP  - 1999 Jan 29
TI  - UCP4, a novel brain-specific mitochondrial protein that reduces membrane
      potential in mammalian cells.
PG  - 326-30
AB  - Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins
      that have been implicated in thermoregulatory heat production and maintenance of 
      the basal metabolic rate. We have identified and partially characterized a novel 
      member of the human uncoupling protein family, termed uncoupling protein-4
      (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and
      possesses features characteristic of mitochondrial transporter proteins. Unlike
      other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and
      adult brain tissues. UCP4 maps to human chromosome 6p11.2-q12. Consistent with
      its potential role as an uncoupling protein, UCP4 is localized to the
      mitochondria and its ectopic expression in mammalian cells reduces mitochondrial 
      membrane potential. These findings suggest that UCP4 may be involved in
      thermoregulatory heat production and metabolism in the brain.
FAU - Mao, W
AU  - Mao W
AD  - Department of Endocrinology, Genentech, Inc., South San Francisco, CA 94080, USA.
FAU - Yu, X X
AU  - Yu XX
FAU - Zhong, A
AU  - Zhong A
FAU - Li, W
AU  - Li W
FAU - Brush, J
AU  - Brush J
FAU - Sherwood, S W
AU  - Sherwood SW
FAU - Adams, S H
AU  - Adams SH
FAU - Pan, G
AU  - Pan G
LA  - eng
SI  - GENBANK/AF110532
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Carrier Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Mitochondrial Uncoupling Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (SLC25A27 protein, human)
RN  - 0 (UCP3 protein, human)
RN  - 0 (Uncoupling Protein 3)
RN  - 555-60-2 (Carbonyl Cyanide m-Chlorophenyl Hydrazone)
SB  - IM
EIN - FEBS Lett 1999 Apr 23;449(2-3):293
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/embryology/*metabolism
MH  - Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology
MH  - Carrier Proteins/analysis/chemistry/genetics/*physiology
MH  - Cell Line
MH  - Cell Survival
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Cloning, Molecular
MH  - Expressed Sequence Tags
MH  - Genes, Plant/genetics
MH  - Humans
MH  - Ion Channels
MH  - Membrane Potentials/drug effects
MH  - *Membrane Transport Proteins
MH  - Mitochondria/metabolism/*physiology
MH  - Mitochondrial Proteins
MH  - Mitochondrial Uncoupling Proteins
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - RNA, Messenger/analysis
MH  - Sequence Homology, Amino Acid
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Uncoupling Protein 3
EDAT- 1999/02/20 00:00
MHDA- 1999/02/20 00:01
CRDT- 1999/02/20 00:00
PHST- 1999/02/20 00:00 [pubmed]
PHST- 1999/02/20 00:01 [medline]
PHST- 1999/02/20 00:00 [entrez]
AID - S0014-5793(98)01713-X [pii]
AID - 10.1016/s0014-5793(98)01713-x [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Jan 29;443(3):326-30. doi: 10.1016/s0014-5793(98)01713-x.