PMID- 10024883
OWN - NLM
STAT- MEDLINE
DCOM- 19990312
LR  - 20190915
IS  - 1097-2765 (Print)
IS  - 1097-2765 (Linking)
VI  - 3
IP  - 1
DP  - 1999 Jan
TI  - A novel human SRB/MED-containing cofactor complex, SMCC, involved in
      transcription regulation.
PG  - 97-108
AB  - A novel human complex that can either repress activator-dependent transcription
      mediated by PC4, or, at limiting TFIIH, act synergistically with PC4 to enhance
      activator-dependent transcription has been purified. This complex contains
      homologs of a subset of yeast mediator/holoenzyme components (including SRB7,
      SRB10, SRB11, MED6, and RGR1), homologs of other yeast transcriptional regulatory
      factors (SOH1 and NUT2), and, significantly, some components (TRAP220,
      TRAP170/hRGR1, and TRAP100) of a human thyroid hormone receptor-associated
      coactivator complex. The complex shows direct activator interactions but, unlike 
      yeast mediator, can act independently of the RNA polymerase II CTD. These
      findings demonstrate both positive and negative functional capabilities for the
      human complex, emphasize novel (CTD-independent) regulatory mechanisms, and link 
      the complex to other human coactivator complexes.
FAU - Gu, W
AU  - Gu W
AD  - Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New
      York, New York 10021, USA.
FAU - Malik, S
AU  - Malik S
FAU - Ito, M
AU  - Ito M
FAU - Yuan, C X
AU  - Yuan CX
FAU - Fondell, J D
AU  - Fondell JD
FAU - Zhang, X
AU  - Zhang X
FAU - Martinez, E
AU  - Martinez E
FAU - Qin, J
AU  - Qin J
FAU - Roeder, R G
AU  - Roeder RG
LA  - eng
SI  - GENBANK/AF135802
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell
JT  - Molecular cell
JID - 9802571
RN  - 0 (Fungal Proteins)
RN  - 0 (IFRD2 protein, human)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (MED6 protein, S cerevisiae)
RN  - 0 (MED6 protein, human)
RN  - 0 (Mediator Complex)
RN  - 0 (Membrane Proteins)
RN  - 0 (NUT2 protein, S cerevisiae)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RGR1 protein, S cerevisiae)
RN  - 0 (Repressor Proteins)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (Transcription Factors, TFII)
SB  - IM
EIN - Mol Cell 1999 Apr;3(4):following 541
MH  - Cloning, Molecular
MH  - Fungal Proteins/chemistry/genetics
MH  - Humans
MH  - Immediate-Early Proteins
MH  - Mediator Complex
MH  - Membrane Proteins
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/chemistry/genetics
MH  - Repressor Proteins/chemistry/*genetics
MH  - Saccharomyces cerevisiae/genetics
MH  - *Saccharomyces cerevisiae Proteins
MH  - Sequence Analysis
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/genetics
MH  - *Transcription Factors
MH  - Transcription Factors, TFII/chemistry/*genetics
MH  - Transcriptional Activation/genetics
EDAT- 1999/02/20 00:00
MHDA- 1999/02/20 00:01
CRDT- 1999/02/20 00:00
PHST- 1999/02/20 00:00 [pubmed]
PHST- 1999/02/20 00:01 [medline]
PHST- 1999/02/20 00:00 [entrez]
AID - S1097-2765(00)80178-1 [pii]
AID - 10.1016/s1097-2765(00)80178-1 [doi]
PST - ppublish
SO  - Mol Cell. 1999 Jan;3(1):97-108. doi: 10.1016/s1097-2765(00)80178-1.