PMID- 10024608
OWN - NLM
STAT- MEDLINE
DCOM- 19990305
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 129
IP  - 2
DP  - 1999 Feb
TI  - Update on interconversions of vitamin B-6 with its coenzyme.
PG  - 325-7
AB  - Biosynthesis of pyridoxal 5'-phosphate (PLP) depends upon the relatively specific
      action of two consecutive enzymes, viz. pyridoxal (pyridoxine, pyridoxamine)
      kinase and pyridoxine (pyridoxamine) phosphate oxidase. Less specific
      phosphatases catalyze hydrolyses of the 5'-phosphates of the vitamers pyridoxal, 
      pyridoxamine, and pyridoxine. From the recognition a generation ago of these
      processes by which the three forms of vitamin B-6 and their 5'-phosphates are
      interconverted, more recent studies have provided a fairly sophisticated
      understanding of the molecular characteristics of the enzymes involved. The
      evolutionary retention of homologous portions of pyridoxal kinase in humans as
      well as bacteria and the most recent finding of a highly conserved region of the 
      pyridoxine (pyridoxamine) phosphate oxidase, also from both prokaryotic and
      eukaryotic organisms, emphasize the importance of these catalysts in the
      formation of a coenzyme that is essential for most organisms. Both kinase and
      oxidase involved in B-6 metabolism are potential targets for pharmacologic
      agents.
FAU - McCormick, D B
AU  - McCormick DB
AD  - Department of Biochemistry, Rollins Research Center, Emory University, Atlanta,
      GA 30322-3050, USA.
FAU - Chen, H
AU  - Chen H
LA  - eng
GR  - DK 38940/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 5V5IOJ8338 (Pyridoxal Phosphate)
RN  - EC 1.4.3.5 (Pyridoxaminephosphate Oxidase)
RN  - EC 2.7.1.35 (Pyridoxal Kinase)
RN  - KV2JZ1BI6Z (Pyridoxine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Molecular Sequence Data
MH  - Pyridoxal Kinase/metabolism
MH  - Pyridoxal Phosphate/*metabolism
MH  - Pyridoxaminephosphate Oxidase/chemistry/genetics/metabolism
MH  - Pyridoxine/*metabolism
MH  - Schizophyllum/genetics
RF  - 33
EDAT- 1999/02/20 00:00
MHDA- 1999/02/20 00:01
CRDT- 1999/02/20 00:00
PHST- 1999/02/20 00:00 [pubmed]
PHST- 1999/02/20 00:01 [medline]
PHST- 1999/02/20 00:00 [entrez]
AID - 10.1093/jn/129.2.325 [doi]
PST - ppublish
SO  - J Nutr. 1999 Feb;129(2):325-7. doi: 10.1093/jn/129.2.325.