PMID- 10024132
OWN - NLM
STAT- MEDLINE
DCOM- 19990324
LR  - 20190915
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 22
IP  - 2
DP  - 1999 Feb
TI  - Differential expression of C-protein isoforms in developing and degenerating
      mouse striated muscles.
PG  - 196-207
AB  - With the aim of clarifying the roles of C-protein isoforms in developing
      mammalian skeletal muscle, we cloned the complementary DNA (cDNAs) encoding mouse
      fast (F) and slow (S) skeletal muscle C-proteins and determined their entire
      sequences. Northern blotting with these cDNAs together with mouse cardiac (C)
      C-protein cDNA was performed. It revealed that in adult mice, C, F, and S
      isoforms are expressed in a tissue-specific fashion, although the messages for
      both F and S isoforms are transcribed in extensor digitorum longus muscle, which 
      has been categorized as a fast muscle. In addition, although C isoform is
      expressed first and transiently during development of chicken skeletal muscles, C
      isoform is not expressed in mouse skeletal muscles at all through the
      developmental stages; S isoform is first expressed, followed by the appearance of
      F isoform. Finally, in dystrophic mouse skeletal muscles, the expression of S
      isoform is increased as it is in dystrophic chicken muscle. These observations
      suggest that mutations in C isoform (MyBP-C) do not lead to any disturbance in
      skeletal muscle, although they may lead to familial hypertrophic cardiomyopathy. 
      We also suggest that the expression of S isoform may be stimulated in
      degenerating human dystrophic muscles.
FAU - Kurasawa, M
AU  - Kurasawa M
AD  - Department of Biology, Faculty of Science, Chiba University, Japan.
FAU - Sato, N
AU  - Sato N
FAU - Matsuda, A
AU  - Matsuda A
FAU - Koshida, S
AU  - Koshida S
FAU - Totsuka, T
AU  - Totsuka T
FAU - Obinata, T
AU  - Obinata T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (Laminin)
RN  - 0 (Muscle Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (myosin-binding protein C)
SB  - IM
SB  - S
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Carrier Proteins
MH  - Cloning, Molecular
MH  - DNA, Complementary/analysis
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Laminin/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred ICR
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - *Muscle Development
MH  - Muscle Fibers, Fast-Twitch/metabolism
MH  - Muscle Fibers, Slow-Twitch/metabolism
MH  - Muscle Proteins/*genetics
MH  - Muscle, Skeletal/*growth & development/*metabolism
MH  - Muscular Dystrophy, Animal/genetics/metabolism
MH  - Myocardium/metabolism
MH  - Protein Isoforms/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 1999/02/19 04:31
MHDA- 2000/06/20 09:00
CRDT- 1999/02/19 04:31
PHST- 1999/02/19 04:31 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/02/19 04:31 [entrez]
AID - 10.1002/(SICI)1097-4598(199902)22:2<196::AID-MUS7>3.0.CO;2-E [pii]
AID - 10.1002/(sici)1097-4598(199902)22:2<196::aid-mus7>3.0.co;2-e [doi]
PST - ppublish
SO  - Muscle Nerve. 1999 Feb;22(2):196-207. doi:
      10.1002/(sici)1097-4598(199902)22:2<196::aid-mus7>3.0.co;2-e.