PMID- 10023777
OWN - NLM
STAT- MEDLINE
DCOM- 19990303
LR  - 20081121
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 10
IP  - 1
DP  - 1999 Jan
TI  - Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.
PG  - 127-36
AB  - An interleukin-18 binding protein (IL-18BP) was purified from urine by
      chromatography on IL-18 beads, sequenced, cloned, and expressed in COS7 cells.
      IL-18BP abolished IL-18 induction of interferon-gamma (IFNgamma), IL-8, and
      activation of NF-kappaB in vitro. Administration of IL-18BP to mice abrogated
      circulating IFNgamma following LPS. Thus, IL-18BP functions as an inhibitor of
      the early Th1 cytokine response. IL-18BP is constitutively expressed in the
      spleen, belongs to the immunoglobulin superfamily, and has limited homology to
      the IL-1 type II receptor. Its gene was localized on human chromosome 11q13, and 
      no exon coding for a transmembrane domain was found in an 8.3 kb genomic
      sequence. Several Poxviruses encode putative proteins highly homologous to
      IL-18BP, suggesting that viral products may attenuate IL-18 and interfere with
      the cytotoxic T cell response.
FAU - Novick, D
AU  - Novick D
AD  - Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
FAU - Kim, S H
AU  - Kim SH
FAU - Fantuzzi, G
AU  - Fantuzzi G
FAU - Reznikov, L L
AU  - Reznikov LL
FAU - Dinarello, C A
AU  - Dinarello CA
FAU - Rubinstein, M
AU  - Rubinstein M
LA  - eng
SI  - GENBANK/AF110460
SI  - GENBANK/AF110798
SI  - GENBANK/AF110799
SI  - GENBANK/AF110800
SI  - GENBANK/AF110801
SI  - GENBANK/AF110802
SI  - GENBANK/AF110803
GR  - AI15614/AI/NIAID NIH HHS/United States
GR  - AI2532359/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (DNA, Complementary)
RN  - 0 (Interferon Inducers)
RN  - 0 (Interleukin-18)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Viral Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
SB  - X
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - COS Cells
MH  - Carrier Proteins/genetics/isolation & purification/*physiology/urine
MH  - Cloning, Molecular
MH  - Cytokines/*biosynthesis
MH  - DNA, Complementary/isolation & purification
MH  - Exons
MH  - Humans
MH  - Injections, Intraperitoneal
MH  - Interferon Inducers/antagonists & inhibitors
MH  - Interferon-gamma/antagonists & inhibitors/biosynthesis
MH  - Interleukin-18/antagonists & inhibitors/*metabolism/physiology
MH  - Introns
MH  - Lipopolysaccharides/antagonists & inhibitors/pharmacology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Poxviridae/genetics
MH  - Recombinant Proteins/administration & dosage
MH  - Sequence Homology, Amino Acid
MH  - Spleen/metabolism
MH  - Th1 Cells/*metabolism
MH  - Viral Proteins/genetics
EDAT- 1999/02/19 00:00
MHDA- 1999/02/19 00:01
CRDT- 1999/02/19 00:00
PHST- 1999/02/19 00:00 [pubmed]
PHST- 1999/02/19 00:01 [medline]
PHST- 1999/02/19 00:00 [entrez]
AID - S1074-7613(00)80013-8 [pii]
PST - ppublish
SO  - Immunity. 1999 Jan;10(1):127-36.