PMID- 10023774
OWN - NLM
STAT- MEDLINE
DCOM- 19990303
LR  - 20190915
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 10
IP  - 1
DP  - 1999 Jan
TI  - RFLAT-1: a new zinc finger transcription factor that activates RANTES gene
      expression in T lymphocytes.
PG  - 93-103
AB  - RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) is a
      chemoattractant cytokine (chemokine) important in the generation of inflammatory 
      infiltrate and human immunodeficiency virus entry into immune cells. RANTES is
      expressed late (3-5 days) after activation in T lymphocytes. Using expression
      cloning, we identified the first "late" T lymphocyte associated transcription
      factor and named it "RANTES Factor of Late Activated T Lymphocytes-1" (RFLAT-1). 
      RFLAT-1 is a novel, phosphorylated, zinc finger transcription factor that is
      expressed in T cells 3 days after activation, coincident with RANTES expression. 
      While Rel proteins play the dominant role in RANTES gene expression in
      fibroblasts, RFLAT-1 is a strong transactivator for RANTES in T cells.
FAU - Song, A
AU  - Song A
AD  - Department of Pediatrics, Stanford University School of Medicine, California
      94305-5208, USA.
FAU - Chen, Y F
AU  - Chen YF
FAU - Thamatrakoln, K
AU  - Thamatrakoln K
FAU - Storm, T A
AU  - Storm TA
FAU - Krensky, A M
AU  - Krensky AM
LA  - eng
SI  - GENBANK/AF132599
GR  - AI-07290/AI/NIAID NIH HHS/United States
GR  - DK35008/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Chemokine CCL5)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KLF13 protein, human)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-rel)
RN  - 0 (Repressor Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites/genetics
MH  - COS Cells
MH  - Cell Cycle Proteins
MH  - Cell Line
MH  - Chemokine CCL5/biosynthesis/*genetics
MH  - DNA-Binding Proteins/biosynthesis/*isolation &
      purification/metabolism/*physiology
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Lymphocyte Activation
MH  - Molecular Sequence Data
MH  - Organ Specificity/genetics
MH  - Promoter Regions, Genetic
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-rel
MH  - Repressor Proteins
MH  - T-Lymphocytes/immunology/*metabolism
MH  - Trans-Activators/physiology
MH  - Transcription Factors/biosynthesis/*isolation &
      purification/metabolism/*physiology
MH  - Transfection
MH  - *Zinc Fingers
EDAT- 1999/02/19 00:00
MHDA- 1999/02/19 00:01
CRDT- 1999/02/19 00:00
PHST- 1999/02/19 00:00 [pubmed]
PHST- 1999/02/19 00:01 [medline]
PHST- 1999/02/19 00:00 [entrez]
AID - S1074-7613(00)80010-2 [pii]
AID - 10.1016/s1074-7613(00)80010-2 [doi]
PST - ppublish
SO  - Immunity. 1999 Jan;10(1):93-103. doi: 10.1016/s1074-7613(00)80010-2.