PMID- 10023074
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20200205
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 227
IP  - 2
DP  - 1999 Feb 18
TI  - Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and
      Pleckstrin-Homology (PH) domains.
PG  - 249-55
AB  - We show here the identification of Duet, a novel molecule bearing
      serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains.
      The kinase domain of Duet shows a homology to that of DAP kinase that is involved
      in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay. The DH-
      and PH-domains are closely related to those of Trio and Kalirin. Trad mRNA is
      specifically expressed in skeletal muscle. Duet protein was localized to
      actin-associated cytoskeletal elements. These data suggest a role of Duet in the 
      cytoskeleton-dependent cell function.
FAU - Kawai, T
AU  - Kawai T
AD  - Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho,
      Nishinomiya, Hyogo, 663-8501, Japan.
FAU - Sanjo, H
AU  - Sanjo H
FAU - Akira, S
AU  - Akira S
LA  - eng
SI  - GENBANK/AB011422
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Kalrn protein, rat)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Trio protein, mouse)
RN  - EC 2.7.11.1 (Death-Associated Protein Kinases)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (TRIO protein, human)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Apoptosis Regulatory Proteins
MH  - Calcium-Calmodulin-Dependent Protein Kinases/chemistry
MH  - *Carrier Proteins
MH  - Cloning, Molecular
MH  - Cytoskeleton/enzymology
MH  - Death-Associated Protein Kinases
MH  - Fluorescent Antibody Technique
MH  - GTP-Binding Proteins/chemistry
MH  - *Guanine Nucleotide Exchange Factors
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/enzymology
MH  - Phosphoproteins/chemistry
MH  - Phosphorylation
MH  - Protein-Serine-Threonine Kinases/*chemistry
MH  - RNA, Messenger/metabolism
MH  - Sequence Analysis, DNA
MH  - Transfection/genetics
EDAT- 1999/02/19 00:00
MHDA- 1999/02/19 00:01
CRDT- 1999/02/19 00:00
PHST- 1999/02/19 00:00 [pubmed]
PHST- 1999/02/19 00:01 [medline]
PHST- 1999/02/19 00:00 [entrez]
AID - S0378-1119(98)00605-2 [pii]
AID - 10.1016/s0378-1119(98)00605-2 [doi]
PST - ppublish
SO  - Gene. 1999 Feb 18;227(2):249-55. doi: 10.1016/s0378-1119(98)00605-2.