PMID- 10022976
OWN - NLM
STAT- MEDLINE
DCOM- 19990614
LR  - 20081121
IS  - 1088-9051 (Print)
IS  - 1088-9051 (Linking)
VI  - 9
IP  - 2
DP  - 1999 Feb
TI  - Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to
      the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily.
PG  - 121-9
AB  - The Growth/differentiation factor (Gdf) 5, 6, 7 genes form a closely related
      subgroup belonging to the TGF-beta superfamily. In zebrafish, there are three
      genes that belong to the Gdf5, 6, 7 subgroup that have been named radar, dynamo, 
      and contact. The genes radar and dynamo both encode proteins most similar to
      mouse GDF6. The orthologous identity of these genes on the basis of amino acid
      similarities has not been clear. We have identified gdf7, a fourth zebrafish gene
      belonging to the Gdf5, 6, 7 subgroup. To assign correct orthologies and to
      investigate the evolutionary relationships of the human, mouse, and zebrafish
      Gdf5, 6, 7 subgroup, we have compared genetic map positions of the zebrafish and 
      mammalian genes. We have mapped zebrafish gdf7 to linkage group (LG) 17, contact 
      to LG9, GDF6 to human chromosome (Hsa) 8 and GDF7 to Hsa2p. The radar and dynamo 
      genes have been localized previously to LG16 and LG19, respectively. A comparison
      of syntenies shared among human, mouse, and zebrafish genomes indicates that gdf7
      is the ortholog of mammalian GDF7/Gdf7. LG16 shares syntenic relationships with
      mouse chromosome (Mmu) 4, including Gdf6. Portions of LG16 and LG19 appear to be 
      duplicate chromosomes, thus suggesting that radar and dynamo are both orthologs
      of Gdf6. Finally, the mapping data is consistent with contact being the zebrafish
      ortholog of mammalian GDF5/Gdf5.
FAU - Davidson, A J
AU  - Davidson AJ
AD  - Department of Molecular Medicine, School of Medicine, University of Auckland,
      Auckland, New Zealand.
FAU - Postlethwait, J H
AU  - Postlethwait JH
FAU - Yan, Y L
AU  - Yan YL
FAU - Beier, D R
AU  - Beier DR
FAU - van Doren, C
AU  - van Doren C
FAU - Foernzler, D
AU  - Foernzler D
FAU - Celeste, A J
AU  - Celeste AJ
FAU - Crosier, K E
AU  - Crosier KE
FAU - Crosier, P S
AU  - Crosier PS
LA  - eng
SI  - GENBANK/AF113022
SI  - GENBANK/AF113023
GR  - P01HD22486/HD/NICHD NIH HHS/United States
GR  - R01RR10715/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genome Res
JT  - Genome research
JID - 9518021
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (GDF5 protein, human)
RN  - 0 (GDF6 protein, human)
RN  - 0 (GDF7 protein, human)
RN  - 0 (Gdf5 protein, mouse)
RN  - 0 (Gdf6 protein, mouse)
RN  - 0 (Gdf7 protein, mouse)
RN  - 0 (Growth Differentiation Factor 5)
RN  - 0 (Growth Differentiation Factor 6)
RN  - 0 (Growth Differentiation Factors)
RN  - 0 (Growth Substances)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Zebrafish Proteins)
RN  - 0 (gdf7 protein, zebrafish)
RN  - 0 (growth differentiation factor 7)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Genome Res. 1999 Feb;9(2):99-100. PMID: 10022974
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Bone Morphogenetic Proteins
MH  - Chromosome Mapping
MH  - DNA/isolation & purification
MH  - Gene Expression Regulation
MH  - Growth Differentiation Factor 5
MH  - Growth Differentiation Factor 6
MH  - Growth Differentiation Factors
MH  - Growth Substances/*genetics/*isolation & purification
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multigene Family/*genetics
MH  - Phylogeny
MH  - Sequence Homology, Amino Acid
MH  - Transforming Growth Factor beta/*genetics
MH  - Zebrafish/*genetics
MH  - Zebrafish Proteins
EDAT- 1999/02/19 00:00
MHDA- 1999/02/19 00:01
CRDT- 1999/02/19 00:00
PHST- 1999/02/19 00:00 [pubmed]
PHST- 1999/02/19 00:01 [medline]
PHST- 1999/02/19 00:00 [entrez]
PST - ppublish
SO  - Genome Res. 1999 Feb;9(2):121-9.