PMID- 10022955
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20191102
IS  - 0949-944X (Print)
IS  - 0949-944X (Linking)
VI  - 209
IP  - 2
DP  - 1999 Feb
TI  - The mouse cornichon gene family.
PG  - 120-5
AB  - As part of a large scale mouse Expressed Sequence Tag (EST) project to identify
      molecules involved in the initiation of mammalian development, a homolog of the
      Drosophila cornichon gene was detected as a mouse maternal transcript present in 
      the two-cell embryo. Cornichon is a multigene family in the mouse: the new gene, 
      Cnih, maps to mouse chromosome 10, another cornichon homolog, Cnil, maps to
      chromosome 14 and two additional cornichon-related loci, possibly pseudogenes,
      localize to chromosomes 3 and 10, respectively. Cnih encodes an open reading
      frame (ORF) of 144 amino acids that is 93% homologous (68% identical) to the
      Drosophila protein, whereas the ORF of Cnil contains two extra polypeptide
      regions not found in these other proteins. Transcripts of Cnih are highly
      abundant in the full grown oocyte and the ovulated unfertilized egg, while Cnil
      message is only detectable after activation of the embryonic genome at the
      eight-cell stage. In situ hybridization shows specific localization of Cnih
      transcripts to ovarian oocytes. The lack of cytoplasmic polyadenylation of the
      maternally inherited Cnih transcript suggests that Cnih mRNA is translated in the
      full grown oocyte before, but not after, ovulation. In Drosophila, cornichon is
      involved in the establishment of both anterior-posterior and dorso-ventral
      polarity via the epidermal growth factor (EGF)-receptor signaling pathway.
      Finding Cnih in the mammalian oocyte opens a new perspective on the investigation
      of EGF-signaling in the oocyte.
FAU - Hwang, S Y
AU  - Hwang SY
AD  - The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
FAU - Oh, B
AU  - Oh B
FAU - Zhang, Z
AU  - Zhang Z
FAU - Miller, W
AU  - Miller W
FAU - Solter, D
AU  - Solter D
FAU - Knowles, B B
AU  - Knowles BB
LA  - eng
SI  - GENBANK/AF022811
GR  - P30CA34196/CA/NCI NIH HHS/United States
GR  - R01LM05110/LM/NLM NIH HHS/United States
GR  - R03HD35252/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Dev Genes Evol
JT  - Development genes and evolution
JID - 9613264
RN  - 0 (Cnih protein, mouse)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Egg Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (cni protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Drosophila Proteins
MH  - Egg Proteins/*genetics
MH  - Embryonic and Fetal Development/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Genes, Insect
MH  - In Situ Hybridization
MH  - *Membrane Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Sequence Alignment
MH  - Transcription, Genetic
EDAT- 1999/02/18 00:00
MHDA- 1999/02/18 00:01
CRDT- 1999/02/18 00:00
PHST- 1999/02/18 00:00 [pubmed]
PHST- 1999/02/18 00:01 [medline]
PHST- 1999/02/18 00:00 [entrez]
AID - 10.1007/s004270050234 [doi]
PST - ppublish
SO  - Dev Genes Evol. 1999 Feb;209(2):120-5. doi: 10.1007/s004270050234.